Alpha-smooth muscle actin expression upregulates fibroblast contractile activity.

By B. Hinz, G. Celetta, J. Tomasek, G. Gabbiani, C. Chaponnier. Molecular Biology of the Cell, 2001

1,340 citations recorded by the source corpus.

Subfields: Cell Biology, Genetics, Mechanical Engineering

View Paper: https://www.semanticscholar.org/paper/dc9d8a0f603dfb0d6ecdd8c2fdcc5d65df0d7b3a

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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. B. Hinz
2. A. Engler
3. P. Janmey
4. Dennis E. Discher
5. Ilya Levental
6. Penelope C. Georges
7. K. Sengupta
8. J. Solon

In Genetics

1. P. Janmey
2. D. Rifkin
3. B. Hinz
4. J. Erler
5. L. Hammerich
6. T. Cox
7. F. Tacke
8. Peter Friedl

In Mechanical Engineering

1. B. Hinz

Citations in the corpus

• Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells (2007, background): “When cultured on thin collagen-coated silicone substrates, they were able to induce wrinkles in the substrate almost as efficiently as lung myofibroblasts, which have a well established contractile functio”
• Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix (2007, methodology): “Mfs activate latent TGF-β1 from self-generated stores in the ECM Autocrine TGF-β1 formation has been suggested as the stimulus for constitutive α-SMA expression in cultured rat lung Mfs (Hinz et al., 2001a).”
• Formation and function of the myofibroblast during tissue repair. (2007, background): “These in vivo stress fibers are first composed of cytoplasmic actins and generate comparably small traction forces (Hinz et al., 2001b).”
• Actin stress fibres (2007, background): “Stress fibres that contain SMA generate more contractile force than normal stress fibres, which contain only - and -cytoplasmic actin (Hinz et al., 2001b).”
• The myofibroblast: paradigm for a mechanically active cell. (2010, background): “Concomitantly, myofibroblast differentiation and a-SMA expression on rigid plastic substrates or in mechanically stressed wounds are suppressed by inhibition of TGFb1 (Hinz et al., 2001a, 2001b).”
• Mechanobiology of tendon. (2006, background): “Increased tension on granulation tissue in rats increases the formation of stress fibers and the expression levels of a-SMA and ED-A fibronectin (Hinz et al., 2001; Serini et al., 1998), which are two protein markers of myofibroblasts.”
• Fibroblast heterogeneity in the cancer wound (2014, background): “The induced expression of –SMA alters cytoskeletal organization, which increases the contractile ability of myofibroblasts (Rønnov-Jessen and Petersen, 1996; Hinz et al., 2001).”
• Fibroblast adaptation and stiffness matching to soft elastic substrates. (2007, background): “Other studies of fibroblasts or other cell types have shown a-smooth muscle actin expression (34), production of calponin (35), expression of filamin (36), and reorganization and change in the of type of intermediate filament expressed (37,38) to be important in regulating the mechanical response of”
• Matrix elasticity directs stem cell lineage specification. (2006, background): “…Sweeney,1 and Dennis E. Discher1,2,3,4,* 1Pennsylvania Muscle Institute 2School of Engineering and Applied Science 3Cell & Molecular Biology Graduate Group 4Physics Graduate Group University of Pennsylvania, Philadelphia, PA 19104, USA *Contact: discher@seas.upenn.edu DOI 10.1016/j.cell.2006.06.044”