Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA.

By Ling-Ling Chen, G. Carmichael. Molecules and Cells, 2009

669 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/dc687d984d93814640bc215bf598bacbdb17298f

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In Molecular Biology

Citations in the corpus

Biogenesis and Function of Nuclear Bodies (2011, background): “Upon hESC differentiation, the expression of Men ε/β ncRNAs increases, resulting in the formation of paraspeckles which retain A-to-I hyperedited mRNAs in the nuclei of differentiated cells [14].”
Non‐coding RNAs: regulators of disease (2010, background): “For instance, the NRON lncRNA is involved in the cytoplasmic-to-nuclear shuttling of the NFAT transcription factor [123], and the lncRNA NEAT1 /MEN ε/β is required for the formation of the nuclear subcompartment paraspeckles in differentiated cells and regulates the movement of primate-specific mRNA”
Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs (2012, background): “Moreover, depletion of NEAT1 is sufficient to cause loss of paraspeckles in the nucleus, andoverexpressing NEAT1, but not paraspeckle-associated proteins, leads to an increase in the number of paraspeckles suggesting an essential role for NEAT1 in paraspeckle formation and/or integrity (61,62,65).”
ADAR1 Limits RIG-I RNA Detection and Suppresses IFN Production Responding to Viral and Endogenous RNAs (2014, background): “found to be involved in cellular RNA distribution (50) and deg-”
LINE-1 Elements in Structural Variation and Disease (2011, background): “For example, inverted Alu elements within the 3′ UTRs of some cellular mRNAs can result in adenosine-to-inosine RNA editing and preferential nuclear retention of the resultant edited mRNAs in differentiated cells (42).”
Linking Long Noncoding RNA Localization and Function. (2016, background): “There are approximately 5–20 paraspeckles in each nucleus of most mammalian cells and NEAT1 is required for the integrity of paraspeckles [30–33].”
Long Noncoding RNAs: Past, Present, and Future (2013, background): “NEAT1 interacts with paraspeckle proteins such as p54/NONO and PSP (Chen and Carmichael 2009; Clemson et al. 2009; Sasaki et al. 2009), and recent evidence suggests that the recruitment of these proteins to form paraspeckles is a dynamic process that requires continuous transcription of NEAT1 (Mao e”