Biogenesis and Function of Nuclear Bodies

By Y. Mao, Bin Zhang, David L. Spector. Trends in Genetics, 2011

663 citations recorded by the source corpus.

Nuclear bodies including nucleoli, Cajal bodies, nuclear speckles, Polycomb bodies, and paraspeckles are membrane-less subnuclear organelles. They are steady-state structures that dynamically respond to basic physiological processes as well as various forms of stress, altered metabolic conditions and alterations in cellular signaling. The formation of specific nuclear bodies has been suggested to follow stochastic and ordered assembly models. In addition, a seeding mechanism has been proposed to assemble, maintain, and regulate particular nuclear bodies. In coordination with noncoding RNAs, chromatin modifiers and other machineries, various nuclear bodies have been shown to sequester and modify proteins, process RNAs and assemble ribonucleoprotein complexes, as well as epigenetically regulate gene expression. Understanding the functional relationships between the three-dimensional organization of the genome and nuclear bodies is essential to fully uncover the regulation of gene expression and its implications in human diseases.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c7a8fbd22a3eb4fa8020c9fe427d72787f6bf7fb

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Citations in the corpus

Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution (2015, background): “This pattern was almost solely nuclear, and showed a ‘clumping’ that may indicate association with specific nuclear bodies [68].”
Long Noncoding RNAs: Past, Present, and Future (2013, background): “…with paraspeckle proteins such as p54/NONO and PSP (Chen and Carmichael 2009; Clemson et al. 2009; Sasaki et al. 2009), and recent evidence suggests that the recruitment of these proteins to form paraspeckles is a dynamic process that requires continuous transcription of NEAT1 (Mao et al. 2011a).”
Competing protein-RNA interaction networks control multiphase intracellular organization (2020, neutral): “, nucleoli, speckles) (Mao et al., 2011; Nizami et al., 2010; Zhu and Brangwynne, 2015), membraneless organelles in the cytosol typically form in a context-dependent manner as a consequence of altered RNA homeostasis (stress granules, SGs; P-bodies, PBs) (Ivanov et al.”
Spatiotemporal control of intracellular phase transitions using light-activated optoDroplets (2016, neutral): “Among dozens of examples include nuclear bodies such as nucleoli, Cajal bodies, and PML bodies, and cytoplasmic germ granules, stress granules and processing bodies ((Mao et al., 2011), (Anderson and Kedersha, 2009), (Buchan and Parker, 2009), (Handwerger and Gall, 2006)).”
Compositional Control of Phase-Separated Cellular Bodies (2016, neutral): “They appear to be functionally important, as inferred from their conservation among evolutionarily distant species (Handwerger et al., 2005) and their tendency to concentrate functionally related groups of molecules (Mao et al., 2011; Mohamad and Bodén, 2010).”