Model systems, lipid rafts, and cell membranes.

By K. Simons, W. Vaz. Annual Review of Biophysics and Biomolecular Structure, 2004

1,649 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dc04323a50e6ef9dfea9e37a20bee5f2802e4f4b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

In Cell Biology

In Molecular Biology

Citations in the corpus

Lipid rafts: contentious only from simplistic standpoints (2006, background): “The classic lipid-raft hypothesis postulates that rafts pre-exist in the plasma membrane 1 , 3 .”
Lipid rafts and membrane dynamics (2005, background): “The tighter packing is due to the saturated hydrocarbon chains in raft sphingolipids and phospholipids compared with the unsaturated fatty acids of phospholipids in the non-raft phase (Simons and Vaz, 2004).”
Upregulated function of mitochondria-associated ER membranes in Alzheimer disease (2012, neutral): “These regions have a liquid-ordered structure with unique biophysical characteristics that differs from the rest of the cell’s liquid-disordered membranes (Simons and Vaz, 2004).”
Cellular cholesterol trafficking and compartmentalization (2008, background): “Because of the rigid sterol backbone, cholesterol is preferentially positioned in close proximity to saturated hydrocarbon chains of neighbouring lipids, as these are more inflexible and elongated compared with those of unsaturated lipid”
Revitalizing membrane rafts: new tools and insights (2010, background): “It has been argued that the chemical composition of the outer monolayer of cell plasma membranes endows them with the propensity for phase separation (if at equilibrium”
Role of cholesterol and lipid organization in disease (2005, background): “Changes in the organization of lipids can have profound effects on cellular functions such as signal transduction and membrane traffickin”