Cellular cholesterol trafficking and compartmentalization
By Elina Ikonen. Nature reviews. Molecular cell biology, 2008
1,379 citations recorded by the source corpus.
Subfields: Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/91e560b0d70a1b006aa47d6c54666d635026a584
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In Molecular Biology
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In Surgery
Citations in the corpus
- Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling (2013, neutral): “Absence of NPC1 causes late endo/lysosomal dysfunction, cholesterol accumulation and is implicated in a lysosomal storage disease that causes liver and neural degeneration in human patients and animal models 27–29 .”
- Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues (2019, background): “Ch l conte is s rictly controlled by three mechanisms: de novo synthesis, uptake and esterification [21].”
- INCREASED HEPATIC SYNTHESIS AND DYSREGULATION OF CHOLESTEROL METABOLISM IS ASSOCIATED WITH THE SEVERITY OF NONALCOHOLIC FATTY LIVER DISEASE (2012, background): “Cholesterol Uptake Pathways Are Downregulated in NAFLD LDL-C is taken up via LDLR and then de-esterified in late endosomes and the FC returned to the plasma membrane or used for cellular needs (Ikonen, 2008; Tabas, 2000).”
- Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness (2014, background): “Inside cells, cholesterol is an essential molecule that plays important roles in the maintenance of membrane structure, signal transduction, and provision of precursor to hormone synthesis (Ikonen, 2008).”
- Membrane curvature at a glance (2015, background): “sphingolipids (such as sphingomyelin) and of PtdCho, and thus disfavor spontaneous curvature (Ikonen, 2008).”
- Cholesterol metabolism and homeostasis in the brain (2015, neutral): “The apoE-cholesterol particle is processed to free cholesterol in lysosome after being endocytosised (Ikonen, 2008; Fagan and Holtzman, 2000) and then transported to membrane.”