Lipid rafts and membrane dynamics

By L. Rajendran, K. Simons. Journal of Cell Science, 2005

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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, neutral): “In addition, membrane microdomains or lipid rafts contain sphingomyelin and cholesterol in tightly packed, liquid-ordered state (Rajendran and Simons 2005).”
Lipid raft microdomains and neurotransmitter signalling (2007, background): “In addition to acting as organizing centres for signalling molecules, both planar lipid rafts and caveolae can facilitate clathrin-independent endocytosi”
Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “The best studied examples of these are ‘‘lipid raft’’ lipids, which include cholesterol and glycosphingolipids (Rajendran and Simons, 2005), which contain straight saturated fatty acid chains, and prefer planar membranes over highly curved ones.”
Insecticidal Genetically Modified Crops and Insect Resistance Management (IRM) (2008, background): “In this context it could be hypothesized that lipid rafts, which are characterized by a high content of GPI-anchored proteins and have been suggested to serve as a platform for various signaling complexes (Sangiorgio et al., 2004; Rajendran and Simons, 2005) may be a common component of both toxicit”