New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

By Christopher A. Hunter. Nature reviews. Immunology, 2005

933 citations recorded by the source corpus.

Subfields: Dermatology, Immunology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/db004422105a2eadebccd48486edd46897321e44

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Citations in the corpus

TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 (2007, background): “It promotes the differentiation of naive T cells into T H 1 cells and inhibits the expansion of effector and memory cell”
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. (2011, background): “Indeed, IL-27 often opposes the action of IL-6 and is the only member of the gp130-related cytokine family to predominantly signal via the latent transcription factor STAT1 instead of STAT3 (14, 55).”
TRUCKs: the fourth generation of CARs (2015, background): “Both IL-23 and IL-27 improve IFN-g production by T and NK cells; some other properties of these cytokines differ [55].”
Interleukin-22: immunobiology and pathology (2015, background): “Uhlig HH, McKenzie BS, Hue S, Thompson C, Joyce-Shaikh B, Stepankova R, Robinson N, Buonocore S, Tlaskalova-Hogenova H, Cua DJ, Powrie F. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.”
Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system (2006, background): “As a consequence, there has been interest in defining the ontogeny of these pathological CD4 + T cells and the factors that regulate their activitie”
IL-17 family cytokines and the expanding diversity of effector T cell lineages. (2007, background): “Concurrent with these findings, Kastelein and colleagues (69, 70) reported the discovery of the first new member of what was to become the five-member IL-12 family (see also Reference 131 in this volume).”