Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells.
By Fanny Chalmin, S. Ladoire, G. Mignot, J. Vincent, M. Bruchard, J. Rémy-Martin, W. Boireau, Alain Rouleau, B. Simon, D. Lanneau and 13 more. Journal of Clinical Investigation, 2010
959 citations recorded by the source corpus.
Subfields: Infectious Diseases, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/dae1c8d33c3a521e64fc5b0b7d73943035f4abde
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In Infectious Diseases
In Molecular Biology
- Raghu Kalluri
- Valerie S. LeBleu
- P. Vader
- M. Wood
- D. Lyden
- Christoph Kahlert
- David W. Greening
- Imre Mäger
Citations in the corpus
- Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “…exosomes contribute to immune suppression in vivo comes from the observation that inhibition of exosome production by a drug to treat high blood pressure, dimethyl amiloride, enhances the antitumor efficacy of the chemotherapeutic drug cyclophosphamide in mouse tumor models (Chalmin et al., 2010).”
- SORTING IT OUT: REGULATION OF EXOSOME LOADING (2014, background): “Exosome-mediated signaling in tumors is thus affected by a variety of stress conditions [111], and promotes tumor progression through communication between the tumor and surrounding stromal tissue, activation of proliferative and angiogenic pathways, promotion of immune suppression, and initiation o”
- Exosomes in cancer: small particle, big player (2015, background): “Hsp72 on tumor-derived exosomes promotes the immunosuppressive activity of MDSCs via autocrine activation of IL-6/STAT3 pathway [63].”
- Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013, neutral): “Drugs targeting EV secretion have been shown to increase chemotherapeutic sensitivities of tumors [123, 124].”
- Exosomes and their roles in immune regulation and cancer. (2015, background): “ndosome-derived exosomes, secreted by tumour cells in modlating the immune response has been highlighted [6–12].”
- The biology, function, and biomedical applications of exosomes (2020, positive): “Tumor – derived exosomal miR-222-3p down-regulates SOCS3 (suppressor of cytokine signaling 3) in monocytes, which promotes STAT3-mediated M2 polarization of macrophages ( 81 ), possibly generating an immunosuppressive microenvironment.”
- Exosome Theranostics: Biology and Translational Medicine (2018, background): “In addition, a recent study has indicated that tumor-derived exosomes expressing HSP72 at the surface can promote antigen-nonspecific immune suppression via myeloid-derived suppressor cells (MDSCs), a group of immature myeloid cells with the ability to suppress T cell activation [108].”
- Extracellular vesicles in cancer: cell-to-cell mediators of metastasis (2016, background): “proposed that MDSC activation involves Hsp72 expressed on tumor exosomes that promotes the activation of signal transducer and activator of transcription 3 (STAT3) in a Toll-like receptor 2 (TLR2/MyD88)-dependent manner (Chalmin et al., 2010).”
- Exosomes in Tumor Microenvironment Influence Cancer Progression and Metastasis (2013, background): “Chalmin and colleagues [45] found that tumor-derived exosomes from different cancer cell lines induce interleukin-6 (IL-6) production in MDSCs through the activation of the Toll-like receptor 2 via the membrane-associated heat shock protein 72 (Hsp72).”