Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease.

By D. Weinstein, Cindy N. Roy, M. Fleming, M. Loda, J. Wolfsdorf, N. Andrews. Blood, 2002

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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. (2004, positive): “In a model that we proposed (12, 34) as an extension of earlier hypotheses (13, 35), IL-6–stimulated increase in plasma hepcidin concentration blocks the release of iron from macrophages that recycle iron from senescent erythrocytes.”
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). (2007, background): “Mutant mice with iron-deficiency anemia or rats fed an iron-deficient diet exhibit lower hepatic hepcidin expression than control animals (6, 17).”
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. (2002, positive): “When the adenomas were removed, the anemia resolved spontaneously (15).”
Identification of an intestinal heme transporter. (2005, background): “…Procedures Cloning of HCP1 To isolate HCP1, tfrhpx/hpx mice were used, since these mice have a highly increased rate of erythropoesis (Huggenvik et al., 1989), low levels of circulating hepcidin (Weinstein et al., 2002), and, consequently, a very high rate of iron absorption (McKie et al., 2000).”