A microenvironmental model of carcinogenesis

By Robert A. Gatenby, Robert James Gillies. Nature Reviews. Cancer, 2008

710 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4cdf835cd3735623b4f2fbd9e594eed079b75d15

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1. D. Hanahan
2. A. Marusyk
3. J. Cantor
4. Jie Zheng
5. M. Greaves
6. Robert James Gillies
7. I. Robey
8. K. Polyak

Citations in the corpus

• Cancer Cell Metabolism: One Hallmark, Many Faces (2012, background): “It has also been suggested that this lactate-driven acidification can promote both tumor invasion and immune evasion (146, 147), which are among the other denoted hallmarks of cancer (8).”
• Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases (2009, background): “It has been argued that metastatic cancers are selected for their ability to export acid (12).”
• Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review). (2012, background): “An acidic microenvironment provides a growth advantage to cancer tissues over normal tissues and enhances the invasion and metastasis of cancer cells (32,33).”
• Modes of resistance to anti-angiogenic therapy (2008, background): “This seemingly preordained return to growth and progression in the face of ostensibly potent angiogenesis inhibitors conflicts with the widely accepted proposition that angiogenesis is an essential capability for the manifestation of lethal cance”
• Causes and Consequences of Increased Glucose Metabolism of Cancers (2008, background): “A corollary to this is the concept of functional equivalence, in which multiple (epi)genetic mechanisms can give rise to similar phenotypes (4), and this principle can explain the welldocumented genetic heterogeneity of cancers (177–180).”
• Defining the Role of Hypoxia-Inducible Factor 1 in Cancer Biology and Therapeutics (2009, unknown): “…activity suggests that increased HIF-1 activity represents a final common pathway in cancer pathogenesis, that is, clonal selection favors those cancer cells in which HIF-1 activity is increased (Semenza, 2000; Vogelstein and Kinzler, 2004; Gillies and Gatenby, 2007; Gatenby and Gillies, 2008).”
• CLONAL EVOLUTION IN CANCER (2012, background): “The cancer ecosystem Tissue ecosystems provide the venue and determinants for fitness selection (the adaptive landscap”
• Intratumor heterogeneity: the Rosetta stone of therapy resistance (2020, background): “In addition to directly influencing tumor cell phenotypes, predictably distinct microenvironmental habitats could provide distinct selective pressures (Gatenby and Gillies, 2008).”