A Heat-Sensitive TRP Channel Expressed in Keratinocytes
By A. Peier, A. Reeve, D. Andersson, A. Moqrich, Taryn J. Earley, A. C. Hergarden, G. M. Story, Sian Colley, John B. Hogenesch, P. McIntyre and 2 more. Science, 2002
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Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe the cloning and characterization of a novel thermosensitive TRP channel. TRPV3 has a unique threshold: It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons.
Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Sensory Systems
View Paper: https://www.semanticscholar.org/paper/da2784438820441a6a01c6258c5713175af9bc2f
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In Cellular and Molecular Neuroscience
In Endocrine and Autonomic Systems
In Sensory Systems
Citations in the corpus
- Handbook of ion channels (2015, background): “TRPV1 opens in response to noxious heat, while TRPV3 and TRPV4 channels are activated by more moderate, warm temperatures, >~30°C (Peier et al. 2002; Nilius et al. 2007).”
- painless, a Drosophila gene essential for nociception. (2003, background): “…of the TRP family was shown to be acti- vated by menthol and cool temperatures, leading to theCalifornia Institute of Technology Pasadena, California 91125 suggestion that the ion channels in the TRP family might play a central role in sensing temperature (McKemy et al., 2002; Peier et al., 2002).”
- Cellular and Molecular Mechanisms of Pain (2009, neutral): “…as receptors for plant-derived irritants, including capsaicin (TRPV1), menthol (TRPM8), and the pungent ingredients in mustard and garlic plants, isothiocyanates, and thiosulfinates (TRPA1) (Bandell et al., 2004; Caterina et al., 1997; Jordt et al., 2004; McKemy et al., 2002; Peier et al., 2002a).”
- TRP channels as cellular sensors (2003, neutral): “Increased temperature also activates TRPV3 (>31 °C”
- Membrane fluidity and its roles in the perception of environmental signals. (2004, background): “A heat-sensitive transient receptor potential channel has been represented as a heat sensor in mammalian keratinocytes [96,114], but no heat sensors have yet been identified in any photosynthetic organisms.”
- TRP Channels (2012, neutral): “also potent sensitizers for temperature activation of the channel (281, 325, 489, 491).”
- Trp ion channels and temperature sensation. (2006, background): “The identification of TRPM8, a menthol- and cold-activated ion channel, demonstrated that various classes of TRP channels are involved in thermosensation and that these thermoTRPs are receptors for naturally occurring sensory compounds (McKemy et al. 2002, Peier et al. 2002).”
- An introduction to TRP channels. (2006, background): “55-11μM ~2 agonist (66-72) I,Ca HEK NADA TRPV1 40nM agonist (66, 95) Ca HEK OLDA TRPV1 258nM agonist (95, 96) Ca HEK OEA TRPV1 2μM 1 agonist (97) I X PDDHV TRPV1 125nM agonist (98) B,Ca CHO PDDHV TRPV4 125nM agonist (99) I, Ca ? PPAHV TRPV1 157nM,667nM agonist (70, 96, 100-102) I, Ca HEK,CHO PI(4,5)”
- Transient receptor potential channels: targeting pain at the source (2009, neutral): “org/IC/ObjectDisplayForward?objectId=32&familyId=12">TRPV3 (Ref”