Hypothalamic KATP channels control hepatic glucose production

By A. Pocai, T. Lam, R. Gutiérrez-Juárez, S. Obici, G. Schwartz, J. Bryan, L. Aguilar-Bryan, L. Rossetti. Nature, 2005

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Effect of in ovo feeding egg white protein, β-hydroxy-β-methylbutyrate, and carbohydrates on glycogen status and neonatal growth of turkeys (2006, background): “Insulin , an inhibitor of hepatic gluconeogenesis (Pocai et al., 2005) may have metabolically shifted the use of dietary protein (EWP) away from gluconeogenesis.”
Impact of Dietary Polyphenols on Carbohydrate Metabolism (2010, background): “nervous system mediates part of the effects of insulin and of other signals such as long chain fatty acids (LCFAs) to exert higher control on hepatic glucose metabolism [128,129].”
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. (2007, methodology): “Studies were performed in conscious, unrestrained, catheterized mice for 90 min as previously described (Pocai et al., 2005).”
From mice to men: insights into the insulin resistance syndromes. (2006, result): “Consistent with this conclusion, it has recently been shown that hepatic vagotomy abolishes the ability of central insulin administration to suppress hepatic glucose production (30).”
The PI3K/AKT pathway in obesity and type 2 diabetes (2018, background): “First, insulin action in the hypothalamus through K (ATP) channels decrease expression of G6PC and hepatic glucose production (HGP) in liver [89, 90].”