Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion 1

By C. Ryckman, Karen Vandal, P. Rouleau, M. Talbot, P. Tessier. Journal of Immunology, 2003

867 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d9af4140fd6ff7a4c4ed6a0afc290317a6d7eb1e

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1. H. Kono
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Citations in the corpus

• Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells (2008, background): “In addition to myeloid cells and MDSC, S100A8/A9 proteins are produced by many tumor cells (40, 41, 46–49) and are chemotactic for target cells expressing their receptor (20, 50), raising the possibility that tumor cell and/or MDSC-secreted S100A8/A9 proteins attract MDSC to tumor sites.”
• Functions of S100 Proteins (2012, background): “These promote actin polymerization in monocytes and neutrophils, likely via a G-protein-coupled receptor [208-210].”
• The inflammatory response to cell death. (2008, background): “Here, a note of caution is warranted because in some systems the immune stimulating activity of HSP has been shown to be due to contaminating microbial molecules (50); (iii) Certain of the S100 family of proteins, which stimulate cytokine production and chemotaxis in vitro (51, 52).”
• IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human Keratinocytes1 (2005, background): “Although their main functions are as yet unclear, they appear to play prominent inflammatory functions (26, 36, 37) and to be involved in the fine regulation of a large number of intraand extracellular activities such as the dynamic of motility of cytoskeletal components or chemotaxis (38).”
• S100A8/A9 in Inflammation (2018, background): “S100A8 and S100A9 induce neutrophil adhesion to fibrinogen in vitro via upregulating Mac-1 (a heterodimer of CD11b and CD18) expression and increasing L-selectin shedding, which is also associated with an elevated intracellular Ca2+ level (61), while S100A9−/− neutrophils exhibit impaired Mac-1 exp”
• S100A8 and S100A9 in inflammation and cancer. (2006, background): “[86] Ryckman C, Vandal K, Rouleau P, Talbot M, Tessier PA.”