Purified hematopoietic stem cells can differentiate into hepatocytes in vivo

By E. Lagasse, Heather Connors, M. Al‐Dhalimy, Michael J. Reitsma, M. Dohse, L. Osborne, Xin Wang, M. Finegold, Irving L. Weissman, M. Grompe. Nature Medicine, 2000

2,402 citations recorded by the source corpus.

Subfields: Hepatology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/d8d758b72642802f000405ca116bf605fa48eddc

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Citations in the corpus

Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. (2002, background): “For instance, cells infused at the time of bone marrow (BM) transplantation contribute to skeletal muscle myoblasts [1,2] and endothelium [3–7] and acquire hepatic [8-10], biliary duct [8-10], lung, gut, skin epithelia [11], and neuroectoderm [12,13].”
Bone marrow-derived progenitor cells in pulmonary fibrosis. (2004, positive): “After transplantation of bone marrow (BM) hematopoietic stem cells or nonhematopoietic mesenchymal stem cells, muscle (2), heart (3), liver (4), and lung (5, 6) cells of donor origin have been detected.”
Recent advances in craniofacial morphogenesis (2006, background): “Systemically injected mouse bone marrow derived cells have given rise to muscle, cartilage, bone, liver, heart, brain, lung, alveolar epithelium, intestine, and, of course, hematocytes (Ferrari et al., 1998; Lagasse et al., 2000; Woodbury et al., 2000; Kotton et al., 2001).”
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. (2001, background): “After bone marrow transplantation, donor-derived stem cells have been found in such diverse nonhematopoietic tissues as skeletal muscle (2), cardiac muscle (3), liver bile ducts (4, 5), and vascular endothelium (6–9).”
Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. (2002, background): “demonstrated that cKitThy1 Sca1+ Lin– cells present in murine BM differentiate into cells with not only hepatocyte phenotype but also hepatocyte function (13).”
Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. (2005, background): “BM cells appear to have the capacity to repopulate many nonhematopoietic tissues, such as neuroectodermal cells (3, 4), skeletal myoblasts (5), CMCs (6, 7), endothelium (6–8), hepatocytes (9), and lung, gut, and skin epithelia (10).”
In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. (2003, background): “After transplantation of bone marrow or enriched hematopoietic stem cells, skeletal lung, gut, and skin epithelia (18), myoblasts (19, 20), cardiac myoblasts (21, 22), endothelium (23, 24), hepatic and biliary duct epithelium (14, 25, 26), or neuroectodermal cells (27, 28) of donor origin can be fou”