Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells.

By R. Schwartz, M. Reyes, L. Koodie, Yuehua Jiang, M. Blackstad, T. Lund, T. Lenvik, Sandra S. Johnson, Wei-Shou Hu, C. Verfaillie. Journal of Clinical Investigation, 2002

1,188 citations recorded by the source corpus.

Subfields: Genetics, Hepatology, Surgery

View Paper: https://www.semanticscholar.org/paper/fb9ad79b68f046eed72253dff015a7fb303b68d9

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Citations in the corpus

In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. (2003, background): “Recently, pluripotent mesenchymal stem cells in adult bone marrow have been described that have the capacity to differentiate into mesenchymal lineage cells, endothelium (31, 32), and endoderm tissue (33) in vitro and in vivo (34).”
Stem cell plasticity: time for a reappraisal? (2005, positive): “Murine and human MAPc can differentiate into functional hepatic tissue in vitro producing albumin and urea and capable of storing glycogen.(51) Thus, different cellular types from the BM or the peripheral blood(52) of hematopoietic(1,3,46,53,54) and non-hematopoietic origin(17,51) share the capacity”
Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. (2002, methodology): “When replated on Matrigel with FGF4 and HGF [29], 50% to 60% of muscle-, brain-, or BM-derived MAPC acquired morphologic and phenotypic characteristics of hepatocyte-like cells.”
Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process (2008, background): “Albeit controversial, there is evidence that MSC can also differentiate into myocytes and cardiomyocytes and even into cells of nonmesodermal origin including hepatocytes and neurons [1–4].”
Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. (2005, background): “was added and cultured for 7 more days (21, 23).”
Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential (2004, background): “…developed mesodermalderived lineages (Reyes et al., 2001), they also developed ectodermal-derived lineages, such as immature neural-like cells and glial-like cells, in vivo (Zhao et al., 2002), as well as endodermal-derived lineages, such as hepatocyte-like cells, in vitro (Schwartz et al., 2002).”
Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies (2007, background): “The group of verfaillie reported that “multipotent adult progenitor cells (MAPCs) differentiate into functional hepatocyte-like cells” (Schwartz et al., 2002) and that they “had phenobarbital-inducible cytochrome P450” (Jiang et al.”
Mesenchymal Stem Cells for Regenerative Medicine (2019, background): “Functional hepatocyte-like cells were obtained from multipotent adult progenitor cells [159].”
Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. (2004, background): “Recent experimental findings have revealed the potential of MSC to differentiate along multiple cell lineages, such as neuronal, myogenic, and hepatocyte-like cells (13,15,17,40).”