Metabolic engineering for the microbial production of 1,3-propanediol.

By C. Nakamura, G. Whited. Current Opinion in Biotechnology, 2003

790 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d83118a4987bfce56f66fa915ac14e0dcadfbbb6

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Citations in the corpus

An optimization framework for identifying reaction activation/inhibition or elimination candidates for overproduction in microbial systems. (2006, background): “Already, a number of compounds are being produced industrially using microbial production systems (Chotani et al., 2000; Nakamura and Whited, 2003), and many efforts are ongoing for synthesizing several others using biological routes (Lee and Schmidt–Dannert, 2002; Martin et al., 2003; Baez–Viveros…”
OptStrain: a computational framework for redesign of microbial production systems. (2004, background): “These biotransformations are aimed at products that range from simple precursor chemicals (Nakamura and Whited 2003; Causey et al. 2004) or complex molecules such as carotenoids (Misawa et al.”
Engineering the third wave of biocatalysis (2012, methodology): “(3R)-4,4-dimethoxy-tetrahydro-2Hpyran-3-ol (15) Recombinantly produced KRED was used for the stereoselective production of 38 kg of this intermediate.”
Multigene Editing in the Escherichia coli Genome via the CRISPR-Cas9 System (2015, background): “An important example of a successful metabolic engineering project is the modification of E. coli to produce 1,3-propanediol, which was developed by Genencor and DuPont (9) and led to a commercial process.”
Industrial applications of enzyme biocatalysis: Current status and future aspects. (2015, background): “Currently, the production of 1,3-propanediol is produced from glycerol by metabolically engineered Saccharomyces cerevisiae and Klebsiella pneumonia (Nakamura and Whited, 2003; Sabra et al., 2010).”
Bacterial-Fungal Interactions: Hyphens between Agricultural, Clinical, Environmental, and Food Microbiologists (2011, background): “cerevisiae and from other bacterial strains to convert dihydroxyacetone phosphate into 1,3-propanediol, which can be used as building blocks for industrial polymers (271).”
Synthetic protein scaffolds provide modular control over metabolic flux (2009, background): “, convert biomass into both bulk and specialty chemical”
Microbial Conversion of Waste Glycerol from Biodiesel Production into Value-Added Products (2013, background): “Although concentrations achieved are still lower than the concentrations from the commercialized process using glucose as substrate [150,151], economic analysis suggests that it is more profitable to generate value-added products like 1,3-PDO ($1.”
Engineering Cellular Metabolism (2008, positive): “…the E. coli strain used for production of 1,3-propanediol (used for production of polymers and solvents), the phosphotransferase (PTS) transport system for glucose uptake and phosphorylation was replaced by a heterologous glucose transporter and an additional hexokinase (Nakamura and Whited, 2003).”