Exercise and the immune system: regulation, integration, and adaptation.

By B. K. Pedersen, L. Hoffman‐Goetz. Physiological Reviews, 2000

1,701 citations recorded by the source corpus.

Subfields: Immunology, Nutrition and Dietetics, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/d7d6b638f849349751d6a84cfd16c732427f24b7

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Citations in the corpus

Exercise, oxidative stress and hormesis. (2008, neutral): “The interaction between exercise-associated stress and the immune system provides an excellent opportunity to study hormesis in this unique condition (Pedersen and Hoffman-Goetz, 2000; Chung et al., 2005).”
Age-related inflammatory cytokines and disease. (2003, background): “It has been well demonstrated that the plasma concentration of IL-6 increases during exercise, even during low-intensity exercise [143,144].”
Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution. (2016, neutral): “During exercise, circulating lymphocytes increase in number and frequency and then fall below pre-exercise levels (Pedersen and Hoffman-Goetz, 2000).”
Evidence for prescribing exercise as therapy in chronic disease (2006, background): “One of the biological functions of muscle-derived IL6 is to inhibit TNF production in muscles and blood (Pedersen & Hoffman-Goetz, 2000; Pedersen et al., 2001).”
Position statement. Part one: Immune function and exercise. (2011, background): “A fascinating cascade of cytokines is now thought to have an important role not only in controlling exercise-induced inflammation, but also in regulating the release and necessary flow of metabolites (221).”
The anti-inflammatory effect of exercise. (2005, background): “The cytokine response to exercise differs from that elicited by severe infections (33, 98, 100, 138).”
Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans (2003, background): “Exercise induces numerous immunological changes (6), and it has recently been observed that working muscles produce (7) and release (8) large amounts of IL-6 into the systemic circulation (9).”
Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020, background): “Following longduration exercise of high intensity, the concentration of lymphocytes falls below pre-exercise values whereas the neutrophil number continues to increase (202, 203).”
Muscle‐derived interleukin‐6: possible biological effects (2001, background): “Recent studies show that several cytokines can be detected in plasma during and after strenuous exercise (Pedersen & Hoffman-Goetz, 2000; Pedersen et al. 2001).”
Production of interleukin‐6 in contracting human skeletal muscles can account for the exercise‐induced increase in plasma interleukin‐6 (2000, background): “Physical exercise induces the release of a cascade of cytokines, including tumour necrosis factor (TNF)-a, interleukin (IL)-1b, IL-6, IL-1 receptor antagonist, TNF receptors and IL-10 (Sprenger et al. 1992; Drenth et al. 1995; Nehlsen-Cannarella et al. 1997; Pedersen & Hoffman-Goetz, 2000).”