Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans

By R. Starkie, S. Ostrowski, Sune Jauffred, M. Febbraio, B. K. Pedersen. The FASEB Journal, 2003

846 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/80fcd9b0d472c33a53e4402d531df9d6a67f24ae

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Citations in the corpus

The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk (2009, methodology): “In contrast, when the subjects performed 3 h of ergometer cycling and received the endotoxin bolus at 2.5 h, the TNF-α response was totally blunted (Starkie et al. 2003).”
Inflammatory mediators in the elderly. (2004, background): “Although IL-6 is often classified as a proinflammatory cytokine, it has also very important anti-inflammatory properties (Starkie et al., 2003) including inhibition of the transcription of the TNF-a gene, stimulation of the production of anti-inflammatory cytokines, and the shedding of TNF-receptors”
A review of lifestyle factors that contribute to important pathways associated with major depression: diet, sleep and exercise. (2013, background): “Data also suggest that exercise-induced IL-6 inhibits TNF-α production in the presence of low-grade inflammation (Starkie et al., 2003).”
Muscles and their myokines (2011, background): “Importantly, we showed that rhIL-6 infusion as well as exercise inhibited the endotoxin-induced increase in circulating levels of TNF-a in healthy humans (Starkie et al., 2003).”
Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease (2014, background): “Treatment of IL-6 enhances insulin-stimulated glucose disposal in humans in vivo, and it increases glucose uptake and fatty acid oxidation in cultured L6 myotubes via activation of adenosine monophosphate-activated protein kinase (AMPK), as well as having an anti-inflammatory effect [101,102], where”
Role of myokines in exercise and metabolism. (2007, background): “Furthermore, both exercise and IL-6 infusion suppress TNFproduction in humans (68).”
The anti-inflammatory effect of exercise. (2005, background): “In addition, rhIL-6 infusion inhibits the endotoxin-induced increase in circulating levels of TNF- in healthy humans (127).”
Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020, methodology): “We infused a very low dose of Escherichia coli endotoxin to healthy subjects, who were randomized to either rest or exercise prior to the endotoxin administration (113).”
Immune function in sport and exercise. (2007, background): “Another important action of IL-6 is that it suppresses production of TNF- , which is a potent activator of inflammation (48).”