A role for Wnt signalling in self-renewal of haematopoietic stem cells

By T. Reya, A. Duncan, L. Ailles, J. Domen, D. Scherer, K. Willert, Lindsay Hintz, R. Nusse, Irving L. Weissman. Nature, 2003

2,347 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/d7c92ff2f95f035a4f948f0210f767fb78b84713

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. S. Morrison
4. Linheng Li
5. M. Clarke
6. K. Willert
7. Irving L. Weissman
8. Nir Yosef

In Oncology

1. Hans Clevers
2. S. Morrison
3. M. Clarke
4. R. Nusse
5. Linheng Li
6. M. Wicha
7. Irving L. Weissman
8. W. Neaves

Citations in the corpus

• Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells (2010, background): “The Wnt signaling pathway has been shown to promote the proliferation of a number of cell types, including hematopoietic stem cells [55].”
• Wnt activity defines colon cancer stem cells and is regulated by the microenvironment (2010, methodology): “1a ) with the CSC phenotype, we assessed Wnt signalling activity in these colon CSC cultures with a TOP–GFP reporter or with control reporters, phosphoglycerate kinase (PGK)–GFP or cytomegalovirus (CMV)–GF”
• Wnt signalling induces maturation of Paneth cells in intestinal crypts (2005, background): “A recent example of the latter is the role of Wnt signalling in the haematopoietic stem cel”
• LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism (2005, background): “These observations signify a common mechanism of self-renewal that may be further applicable to adult stem cell populations that require Wntdependent signaling (Reya et al., 2003).”
• Hematopoiesis: an evolving paradigm for stem cell biology. (2008, background): “The Wnt/b-catenin and Notch-Delta signaling pathways influence the function of adult HSCs. Treatment of purified HSCs with Wnt3a protein leads to a modest increase in engrafting cells (Reya et al., 2003).”
• Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “In the hematopoietic system, Notch signaling (Calvi et al., 2003) and Wnt signaling are sufficient to promote adult HSC self-renewal in culture (Reya et al., 2003; Willert et al., 2003).”
• FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis (2009, background): “…growth factor (FGF), epidermal growth factor (EGF), and the transforming growth factor (TGFb), all of which have been shown to affect self-renewal capacity both c. in vivo and in vitro (Battista et al., 2006; Doetsch et al., 2002a; Jin et al., 2003; Palma et al., 2005; Reya et al., 2003).”