Short RNAs repress translation after initiation in mammalian cells.

By Christian P. Petersen, Marie-Ève Bordeleau, J. Pelletier, Phillip A. Sharp. Molecules and Cells, 2006

856 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d7b37c2496e58e4e21e7fcf3359fb049be254f13

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Citations in the corpus

Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “miRISC can bind mRNA and inhibit its translation (Petersen et al., 2006; Pillai et al., 2005).”
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. (2006, background): “Other studies have suggested that translation inhibition occurs after initiation, based on the observation that miRNAs and some targets remain associated with polysomes (Olsen and Ambros 1999; Kim et al. 2004; Nelson et al. 2004; Petersen et al. 2006).”
Mechanisms of microRNA‐mediated gene regulation (2007, background): “was shown to be translationally repressed and associated with polysomes [ 18 ].”
MicroRNAs in development and disease. (2011, background): “support of this mechanism, cap-independent translation of mRNAs is also successfully inhibited by recombinant miRNA (483).”
Regulation of mRNA translation and stability by microRNAs. (2010, background): “by the miRNA machinery (117, 121), in marked contrast to other studies (46, 91, 95, 97).”
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA (2011, background): “MicroRNAs (miRNA) are known to regulate gene expression by binding to the 30 UTR of target mRNAs in the cytoplasm, resulting in mRNA destabilization and translational repression (Humphreys et al, 2005; Pillai et al, 2005; Petersen et al, 2006; Chendrimada et al, 2007).”
MicroRNAs in body fluids—the mix of hormones and biomarkers (2011, positive): “In mammals, gene regulation mediated by miRNAs is accomplished by imperfect base pairing together with protein translational repression of the target gene”
Gene silencing by microRNAs: contributions of translational repression and mRNA decay (2011, result): “, an idea that was supported by subsequent studies in mammalian cell culture”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “Experiments performed with mammalian cells provided evidence supporting miRNA inhibition of translation at both the initiation and elongation stages [183, 187].”
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (2008, background): “In two studies that used reporter mRNAs targeted by either synthetic or endogenous miRNA”