The conserved KMN network constitutes the core microtubule-binding site of the kinetochore.

By I. Cheeseman, J. Chappie, E. Wilson-Kubalek, A. Desai. Cell, 2006

1,069 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d7991f0fe8194162f75fa3abb7f5a3a83125f450

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In Cell Biology

1. A. Musacchio
2. E. Salmon
3. S. Lens
4. R. Medema
5. E. Voest

In Molecular Biology

1. A. Musacchio
2. E. Salmon
3. S. Lens
4. R. Medema
5. E. Voest

Citations in the corpus

• Microtubule attachment and spindle assembly checkpoint signaling at the kinetochore (2012, background): “relative to the outer kinetochore is unchanged (2).”
• The spindle-assembly checkpoint in space and time (2007, background): “Before mitosis, other evolutionarily conserved proteins, including Spc105 (KNL-1 in Caenorhabditis elegans ) and the Mtw1 (MIS12 in humans), Ndc80 (HEC1 in humans) and minichromosome maintenance protein-21 (MCM21) complexes, are recruited to the kinetochore outer plate to form attachment sites for ”
• Shared and separate functions of polo-like kinases and aurora kinases in cancer (2010, background): “In this conformation, it can phosphorylate several kinetochore-associated proteins, such as highly expressed in cancer (HEC1; also known as NDC80), DSN1 (also known as KNL3) and KNL1 (also known as CASC5 or blinkin) thereby modifying the microtubule binding affinity of the KMN network”
• Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. (2006, positive): “In support of this, recent evidence from C. elegans and human cells suggests that the Ndc80 complex directly binds MTs, and this binding is regulated, in part, by Aurora B kinase (Cheeseman et al., 2006 [this issue of Cell]).”
• Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling (2013, background): “In a few well-characterized cases, phosphorylation negatively regulates protein interactions at the kinetochore (e.g., Cheeseman et al., 2006; DeLuca et al., 2006; Meadows et al., 2011; Rosenberg et al., 2011).”