Shared and separate functions of polo-like kinases and aurora kinases in cancer

By S. Lens, E. Voest, R. Medema. Nature Reviews. Cancer, 2010

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Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development (2011, background): “Aurora kinases have recently received much attention owing to their possible involvement in tumor development and their potential therapeutic value (Keen and Taylor, 2004; Lens et al., 2010; Perez de Castro et al., 2008).”
A Landscape of Driver Mutations in Melanoma (2012, background): “PP6 negatively regulates levels of the melanoma oncogeneCCND1 during G1 phase of the cell cycle (Stefansson and Brautigan, 2007) and is the major T-loop phosphatase for the mitotic kinase, Aurora A (AurA), which is amplified in a number of human cancers (Lens et al., 2010; Zeng et al., 2010).”
Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B (2012, neutral): “IB: HA (AURKB) HA–AURKB – – + – + – FLAG–AURKB-[1-200] FLAG–AURKB-[201-344]”