The spindle-assembly checkpoint in space and time

By A. Musacchio, E. Salmon. Nature reviews. Molecular cell biology, 2007

2,366 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4c4561a49994e093514ae2c30826065d7e99ddae

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Citations in the corpus

The cell cycle and cancer (2012, background): “If the sensor mechanisms detect aberrant or incomplete cell cycle events (eg DNA damage), checkpoint pathways carry the signal to effectors that can trigger cell cycle arrest until the problem is resolved [10,11].”
Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis (2009, background): “A surveillance mechanism called the mitotic checkpoint (also known as the spindle assembly checkpoint) is the primary guard against chromosome missegregatio”
Causes and consequences of aneuploidy in cancer (2012, background): “Accurate chromosome segregation is achieved through carefully orchestrated interactions between the mitotic spindle, kinetochores and cohesio”
Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. (2009, neutral): “1Ludwig Institute for Cancer Research 2Department of Cell and Molecular Medicine, University of California at San Diego 9500 Gilman Drive, La Jolla, CA 92093-0670, USA 3The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA 4Department of Biochemistry and Biophysics, ”
Cell cycle, CDKs and cancer: a changing paradigm (2009, background): “Once the genetic material is duplicated, proper chromosome segregation is controlled by the spindle assembly checkpoint (SAC), a signalling pathway that modulates CDK1 activity and prevent defects in chromosome segregatio”
Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. (2008, background): “It is well established that antimitotic compounds activate the spindle assembly checkpoint (SAC) leading to mitotic arrest (Musacchio and Salmon, 2007).”
Mitotic catastrophe: a mechanism for avoiding genomic instability (2011, background): “This spindle assembly checkpoint (SAC; also known as the mitotic checkpoint) prevents anaphase, and hence chromosome missegregation, in cells with spindle defect”
Cohesin: its roles and mechanisms. (2009, background): “Separase is only (fully) activated when all chromosomes have bioriented, which liberates the APC/C’s Cdc20 activator protein from sequestration by its Mad2 inhibitor (116, 119).”
The spindle assembly checkpoint. (2012, background): “reaction appears to be inhibited away from kinetochores, most likely via a mechanism that blocks the recruitment of O-Mad2 to the core complex [5,63,69].”
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq (2021, neutral): “Intriguingly, many genes implicated in chromosome segregation were among the top drivers of heterogeneity, including TTK, SPC25, and DSN1 (Figure 5B; Musacchio and Salmon, 2007).”
Protein Metamorphosis: The Two-State Behavior of Mad2 (2008, background): “A cell-cycle surveillance system called the spindle checkpoint monitors the proper attachment of microtubules to kinetochores (Bharadwaj and Yu, 2004; Musacchio and Salmon, 2007).”