Microtubule attachment and spindle assembly checkpoint signaling at the kinetochore
By Emily A. Foley, T. Kapoor. Nature reviews. Molecular cell biology, 2012
630 citations recorded by the source corpus.
In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore, a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches chromosomes to spindle microtubules, modulates the stability of these attachments and relays the microtubule-binding status to the spindle assembly checkpoint (SAC), a cell cycle surveillance pathway that delays chromosome segregation in response to unattached kinetochores. Recent studies are shaping current thinking on how each of these kinetochore-centred processes is achieved, and how their integration ensures faithful chromosome segregation, focusing on the essential roles of kinase–phosphatase signalling and the microtubule-binding KMN protein network.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/696a937386f5d4111c69b446faf217c18085fce3
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Citations in the corpus
- How Taxol/paclitaxel kills cancer cells (2014, background): “Unattached kinetochores, which have not made stable attachments to microtubules, activate a signal transduction cascade that delays mitotic progression by inhibiting the anaphasepromoting complex/cyclosome (Kops et al., 2005; Lara-Gonzalez et al., 2012; Foley and Kapoor, 2013).”
- Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “The identity of the coupler and the nature of its kinetics remain controversial [1184, 1185, 1186, 1187, 1188, 1189, 1190].”
- Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling (2013, background): “Because the minimal kinetochore recruitment domain of Bub1 coincides with the Bub3-binding domain, and because it is known that Bub1 and Bub3 reinforce each other in kinetochore localization (Taylor and McKeon, 1997; Taylor et al., 1998; Sharp-Baker and Chen, 2001; Millband and Hardwick, 2002;…”