Cell cycle and death control: long live Forkheads.

By B. Burgering, G. Kops. TIBS -Trends in Biochemical Sciences. Regular ed, 2002

726 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d74d4a4d5bcc757cae408f6b86381ec126fa97c4

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Citations in the corpus

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons (2003, background): “, 2000) and are targets of phosphatidylinositol 3-kinase (PI3-K) signaling, which regulates their activity via phosphorylation mediated by protein kinase B/Akt and serum and glucocorticoid–induced kinase (SGK; Burgering and Kops, 2002).”
Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. (2003, background): “In addition to modulating translation, Akt regulates transcription through the forkhead-related FOXO family of transcription factors FOXO1, FOXO3a, and FOXO4 (Burgering and Kops 2002) by phosphorylating these proteins at three conserved serine/threonine residues.”
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction (2007, background): “FOXO factors regulate metabolism and confer stress resistance (Burgering & Kops, 2002; Accili & Arden, 2004).”
Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5 (2008, neutral): “FoxO1 is phosphorylated and inactivated by PI(3)K–Ak”
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity (2010, background): “In mammals, FoxO proteins also serve as potential tumour suppressors, because all of the FoxO proteins have the ability to induce cell cycle arrest, DNA repair and apoptosi”
Targeting phosphoinositide 3-kinase: moving towards therapy. (2008, background): “The latter allow binding of 14-3-3 proteins, which causes the retention of the FOXO/14-33 complex in the cytosol [57].”
The role of FoxO in the regulation of metabolism (2008, background): “In addition, FoxO reduces the expression of the G1-phase cyclins D1 and D2 as well as the G2–M-phase cyclin B (Burgering and Kops, 2002; Furukawa-Hibi et al., 2005).”
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (2006, neutral): “Regulation of FOXO proteins has been extensively characterized in the context of growth-factor signaling (reviewed in Burgering and Kops, 2002; Van Der Heide et al., 2004).”