Thymopoiesis independent of common lymphoid progenitors

By D. Allman, A. Sambandam, Sungjune Kim, Juli P. Miller, Antonio J. Pagán, D. well, A. Meraz, A. Bhandoola. Nature Immunology, 2003

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Subfields: Immunology

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Transcription factors in myeloid development: balancing differentiation with transformation (2007, background): “However, whereas the link between CLPs and B-cell development seems to be established, their role as the cell of origin of T cells has been challenge”
The Many Faces of IL-7: From Lymphopoiesis to Peripheral T Cell Maintenance (2005, background): “genitors (8, 9), sustained expression of IL-7R chain in lym-”
Causes, consequences, and reversal of immune system aging. (2013, positive): “The most immature intrathymic progenitors, which have been termed early T lineage progenitors (ETPs), generate CD4 – CD8 – double-negative (DN) progeny that ultimately become mature CD4 + Th cells and CD8 + cytotoxic T cells (35).”
Immunosenescence of ageing (2007, background): “Other data suggest that T cell progenitors are derived not from CLPs but from early Tlineage progenitors (ETPs), defined by surface expression of (Lin−, CD44+, c-Kithi, IL-7Rαneg/lo) [19].”
Age-related changes in lymphocyte development and function (2004, background): “Two studies have localized T cell progenitor activity within the DN1 fraction to two subpopulations of cells called early T lineage progenito”