A Topoisomerase IIß-Mediated dsDNA Break Required for Regulated Transcription

By B. Ju, V. Lunyak, V. Perissi, Ivan Garcia-Bassets, D. Rose, Christopher K. Glass, Michael G. Rosenfeld. Science, 2006

812 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d5e833ae51e336de2a47abd539d65c28dd8fe6ec

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Citations in the corpus

Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer (2009, positive): “( Ju et al., 2006 ) coupled with ChIP sequencing (ChIP-seq) analysis to detect potential DNA breaks in response to DHT, genotoxic stress, or both.”
Androgen-induced TOP2B mediated double strand breaks and prostate cancer gene rearrangements (2010, background): “Estrogen receptor signaling has been reported to recruit the TOP2 isoform TOP2B to regulatory regions of estrogen receptor target genes, leading to TOP2B-mediated DSB”
All tangled up: how cells direct, manage and exploit topoisomerase function (2011, background): “The formation of replication initiation complexes at the human ORS8 origin, (a late-firing origin), as well as at the lamin B2 origin, has also been reported to require DNA cleavage by topo IIβ — a topoisomerase associated with repair and developmen”
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. (2012, background): “For example, PARP-1 has been shown to function as a promoter-specific ‘‘exchange factor’’ that promotes the release of inhibitory coregulators and the recruitment of stimulatory coregulators during transcriptional regulation (Ju et al. 2004, 2006; Pavri et al. 2005; Stilmann et al. 2009).”
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs (2010, neutral): “:3) mice die at birth from neurological defects probably related to the critical role of Top2 b in transcription (Ju et al., 2006; Perillo et al., 2008).”
The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes (2008, background): “ChIP experiments suggest that binding of HMG and H1 is mutually exclusive and that association of HMG (coupled with dissociation of H1) to nucleosomes assembled on promoters is associated with transcriptional activation (Ju et al., 2006).”
The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets (2010, positive): “…PARP-1 may displace the linker histone H1 from nucleosomes by PARylating it or by competing for overlapping binding sites on the nucleosomes (Ju et al., 2006; Kim et al., 2004; Krishnakumar et al., 2008). lecular Cell 39, July 9, 2010 ª2010 Elsevier Inc. 9 (A) Alignment of the catalytic…”
Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes (2015, positive): “Incidentally, Topo IIb-mediated DSBs were previously shown to be essential for estradiol-stimulated activation of gene expression (Ju et al., 2006).”
DNA topoisomerase II and its growing repertoire of biological functions (2009, neutral): “used chromatin immunoprecipitation to demonstrate that TOP2β localizes to promoters of genes of which expression is activated by nuclear hormone receptors (but not to many other promoters undergoing active transcription”
Quadruplex DNA: sequence, topology and structure (2006, background): “Resolution of the requirement for duplex unwinding in promoter sequences in order for the G-rich strand to transiently become singlestranded, may be achieved by strand scission; it has been recently reported that DNA topoisomerase II produces double-strand breaks in promoter sequences (106), which c”
PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes (2017, background): “…Mediator for active Cdk8-negative Mediator during retinoic acidregulated activation (Pavri et al. 2005) or the estrogen-dependent recruitment of the TopoIIβ-containing activation complex in exchange for corepressor complexes present at the promoters of estrogen-responsive genes (Ju et al. 2006).”