All tangled up: how cells direct, manage and exploit topoisomerase function

By S. Vos, E. Tretter, B. Schmidt, J. Berger. Nature reviews. Molecular cell biology, 2011

612 citations recorded by the source corpus.

Topoisomerases are complex molecular machines that modulate DNA topology to maintain chromosome superstructure and integrity. Although capable of stand-alone activity in vitro, topoisomerases are frequently linked to larger pathways and systems that resolve specific DNA superstructures and intermediates arising from cellular processes such as DNA repair, transcription, replication and chromosome compaction. Topoisomerase activity is indispensible to cells, but requires the transient breakage of DNA strands. This property has been exploited, often for significant clinical benefit, by various exogenous agents that interfere with cell proliferation. Despite decades of study, surprising findings involving topoisomerases continue to emerge with respect to their cellular function, regulation and utility as therapeutic targets.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/a1f8283606d3c88ac281ef1ea461b31c367e5dd6

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In Molecular Biology

1. Li-Huei Tsai
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In Oncology

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Citations in the corpus

• Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes (2015, positive): “Etoposide introduces DSBs by targeting Topo II (Vos et al., 2011).”