Disruption of differentiation in human cancer: AML shows the way

By Daniel G. Tenen. Nature Reviews. Cancer, 2003

689 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e4f55471ff03a276f417ad96412cefe4755736a0

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Citations in the corpus

Cancer stem cells: lessons from leukemia. (2005, background): “This concept is supported by a correlation between genes required for normal hematopoietic development and those perturbed in leukemia [ 23 ] and by the recent demonstration that Bmi-1 is required for selfrenewal of both normal and leukemic HSCs in mice [24,25].”
Hematopoiesis: a human perspective. (2012, background): “A detailed description of these and other molecular pathways implicated in hematological disorders is the subject of a number of excellent reviews (Tenen, 2003).”
Phosphorylation of C/EBPα Inhibits Granulopoiesis (2004, background): “Thus, multiple mechanisms that result in inhibition of C/EBP protein function contribute to myeloid leukemias ( 44 ).”
Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis (2015, neutral): “Arising from the disruption of regulated myeloid differentiation (Tenen, 2003), AML results in a disordered developmental hierarchy wherein leukemic stem cells (LSCs) are capable of re-establishing the disease in immunodeficient mice (Bonnet and Dick, 1997).”
Transcription factors in myeloid development: balancing differentiation with transformation (2007, background): “Furthermore, dysregulation of transcription factor activity has an important role in leukaemia, implicating these genes as potential targets for therapeutic intervention in myeloid and other cancer”
Stem cell gene expression programs influence clinical outcome in human leukemia (2011, background): “In AML, stem cell regulation and differentiation are abnormal; self-renewal is much greater in LSCs than in HSCs, and differentiation is deregulated and highly variable among genetic and morphological subtype”
Origins of chromosome translocations in childhood leukaemia (2003, background): “These same genes are crucial for the normal function of haematopoietic stem cells, as shown by knockout experiments in mic”