Transcriptional repression mediated by repositioning of genes to the nuclear lamina

By Karen L. Reddy, Joseph M. Zullo, E. Bertolino, Harinder Singh. Nature, 2008

816 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d492a960b78515ca92f6d0845ae71dce922c5acb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Nuclear architecture of rod photoreceptor cells adapts to vision in mammalian evolution. (2009, background): “Targeting to the nuclear periphery suppresses transcription of some, but not all, genes (Finlan et al., 2008; Kumaran and Spector, 2008; Reddy et al., 2008).”
Recombination centres and the orchestration of V(D)J recombination (2011, background): “— perhaps most directly by the finding that forced recruitment of an expression cassette to the inner nuclear membrane results in transcriptional repressio”
Molecular maps of the reorganization of genome – nuclear lamina interactions during differentiation (2010, background): “…of genes to the NL can, at least in certain genomic contexts, lead to reduced gene expression (Finlan et al., 2008; Kumaran and Spector, 2008; Reddy et al., 2008), and depletion of Lamin B in Drosophila causes activation of a gene cluster that is normally silent and located at the NL…”
Lamin B1 loss is a senescence-associated biomarker (2012, methodology): “Mice were treated and mRNA was collected and analyzed as described in Figure 4F.”
Charting histone modifications and the functional organization of mammalian genomes (2011, background): “Remarkably, tethering experiments show that interaction with the nuclear lamina is not only correlative but is also causal in reducing gene expressio”
Chromosome territories. (2010, background): “They found that some genes were suppressed when closely associated with the envelope, but that others were not (Finlan et al. 2008; Kumaran and Spector 2008; Reddy et al. 2008).”
A decade of 3C technologies: insights into nuclear organization. (2012, background): “Targeting specific factors to these arrays can sometimes—but not always—induce repositioning, as was seen for lamin-associated proteins that can direct loci to the nuclear periphery (Finlan et al. 2008; Kumaran and Spector 2008; Reddy et al. 2008).”
Single-cell dynamics of genome-nuclear lamina interactions. (2013, positive): “Contact of a LAD with the NL may help to repress the genes within this LAD, which is consistent with studies showing that artificial anchoring of genes to the NL can lead to reduced transcriptional activity (Dialynas et al., 2010; Finlan et al., 2008; Reddy et al., 2008).”
Functional and mechanistic diversity of distal transcription enhancers (2011, positive): “For example, artificial tethering of reporter genes to the nuclear lamina or nuclear periphery has been shown to result in downregulation of the reporter and of neighboring genes, although not all genes are affected (Andrulis et al., 1998; Finlan et al., 2008; Reddy et al., 2008).”
The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes (2008, background): “Relocating genes to the nuclear periphery may thus be a mechanism to silence genes (Reddy et al., 2008).”