Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation

By Robert A. Waterland, R. Jirtle. Molecular and Cellular Biology, 2003

1,998 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/d4090ec030d2157ae627e36316abb9dee65efb02

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Citations in the corpus

Epigenetic plasticity and the hallmarks of cancer (2017, background): “Physiologic methylation of repetitive DNA is dependent on folate (75), whereasmaintenance of unmethylatedCpG islands requires vitaminC,which is critical for demethylase activity (76).”
Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study (2007, background): “Epigenetic regulation, involving DNA methylation, may be another mechanism of nutritional programming, as demonstrated in animal models [43–45].”
Gene-environment interplay and psychopathology: multiple varieties but real effects. (2006, background): “A particularly striking, albeit very unusual, example of epigenetic effects derived from a study of the effects of maternal diet on the coat colour of the offspring of a particular species of mouse (Waterland & Jirtle, 2003).”
Phenotypic plasticity and the epigenetics of human disease (2007, background): “84 ), and methylation supplementation can cause methylation and silencing of a retroposon in mice with silencing of the nearby agouti coat-colour gen”
Ten Putative Contributors to the Obesity Epidemic (2009, positive): “For example, methyl supplementation of female mice before and during pregnancy induces DNA hypermethylation at “metastable epialleles” such as agouti viable yellow (Avy) (Waterland and Jirtle, 2003) and axin fused (Waterland et al.”
Inherited epigenetic variation — revisiting soft inheritance (2006, background): “In the case of the mouse A vy epiallele ( Table 1 ), dietary supplements (for example, folic acid and vitamin B 12 ) that increase the abundance of the central methyl donor metabolite S -adenosylmethionine elevate DNA methylation of the upstream IAP element and suppress Agouti overexpressio”
Zinc requirements and the risks and benefits of zinc supplementation. (2006, background): “Recent studies of maternal epigenetics and methyl supplements, including diets that contain zinc supplements [124,125], are ‘‘the first report of an effect of dietary methyl supplements on gene imprinting and specific gene expression’’ and it was concluded that the investigation ‘‘demonstrates that ”
Nutrition and epigenetics: An interplay of dietary methyl donors, one-carbon metabolism, and DNA methylation (2012, positive): “A methyl donor-supplemented maternal diet shifted the distribution of coat color phenotype towards brown in comparison to unsupplemented mothers [24].”
Child health, developmental plasticity, and epigenetic programming. (2011, neutral): “(258, 259) have shown that food supplementation”
Epigenetics and the biological definition of gene x environment interactions. (2010, background): “For example, variations in the diet of mice during gestation or later in development, such as the early postweaning period, can stably alter the methylation status of the DNA (Cooney, Dave, & Wolff, 2002; Waterland & Jirtle, 2003; Waterland, Lin, Smith, & Jirtle, 2006; Whitelaw & Whitelaw, 2006).”