A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2

By J. Qi, Q. Ebrahem, N. Moore, Gillian Murphy, L. Claesson‐Welsh, M. Bond, A. Baker, B. Anand-Apte. Nature Medicine, 2003

681 citations recorded by the source corpus.

Subfields: Cancer Research, Hematology, Ophthalmology

View Paper: https://www.semanticscholar.org/paper/d40486e0f19eb82c97876e2d4586c9c7398834ba

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Gillian Murphy
2. Hideaki Nagase
3. Galina Gabriely
4. S. Gill
5. A. Newby
6. Peter S. Linsley
7. Anna M. Krichevsky
8. E. Koivunen

In Hematology

1. Gillian Murphy
2. A. Newby
3. S. Gill
4. Hideaki Nagase
5. E. Koivunen
6. M. Björklund
7. W. Parks

In Ophthalmology

1. O. Strauß

Citations in the corpus

• The role of TIMPs in regulation of extracellular matrix proteolysis. (2015, background): “Additionally, TIMP3 has been shown to antagonize vascular endothelial growth factor (VEGF) signalling by binding directly to the VEGF receptor [18,19].”
• Metalloproteinases and their inhibitors: regulators of wound healing. (2008, background): “In addition to their ability to inhibit MMPs, it has been demonstrated that TIMPs have MMPindependent functions (Baker et al., 2002), as exemplified by TIMP3 and its potent inhibition of angiogenesis (Qi et al., 2003).”
• The Role of Macrophage Phenotype in Vascularization of Tissue Engineering Scaffolds (2014, positive): “3a), which inhibits not only the enzymatic activity of MMP9 but also VEGF signaling, by blocking its binding to VEGF receptor 2 to result in potent inhibition of angiogenesis [50].”
• Progress in matrix metalloproteinase research. (2008, background): “TIMP-3 can also bind to vascular endothelial growth factor (VEGF) receptor 2 and inhibits downstream signalling of VEGF and angiogenesis (Qi et al., 2003).”
• Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. (2005, background): “The reasons for this are obscure but could involve any of the several effects of TIMPs that are unrelated to MMP inhibition (15, 218).”
• Gelatinase-mediated migration and invasion of cancer cells. (2005, background): “TIMP-3 can directly inhibit angiogenesis through blockage of VEGF binding to the VEGF receptor-2 (Qi et al., 2003).”
• MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators (2008, background): “TIMP3 is a tissue inhibitor of MMPs that inhibits angiogenesis and tumor cell infiltration and also induces apoptosis (2, 48).”
• The retinal pigment epithelium in visual function. (2005, background): “The RPE is known to produce and to secrete a variety of growth factors (589) as well as factors that are essential for maintenance of the structural integrity of retina (104, 557) and choriocapillaris (638), e.g., different types of tissue inhibitor of matrix metalloprotease (TIMP) (8, 138, 155, 451”