The retinal pigment epithelium in visual function.
By O. Strauß. Physiological Reviews, 2005
2,753 citations recorded by the source corpus.
Subfields: Molecular Biology, Ophthalmology
View Paper: https://www.semanticscholar.org/paper/0f0c7ec67afa9347e0b4a1a4ae97b7650a033b6b
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In Molecular Biology
In Ophthalmology
Citations in the corpus
- Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex (2012, background): “…pigment granules composed of lipidcontaining residues of lysosomal digestion, which generate reactive oxygen species upon excitation with blue light, thereby making the aged RPE more susceptible to oxidative damage (Strauss, 2005)(also see reviews in this issue by Boulton, Handa, Sparrow).”
- Inflammation and its role in age-related macular degeneration (2016, background): “RPE cells are responsible for many tasks in the eye including maintaining the functionality of the overlying photoreceptor cells, protection of the retina from excessive light, formation of blood-retinal barrier in conjunction with the vascular endothelium, and immune defence of the central retina (”
- The Impact of Oxidative Stress and Inflammation on RPE Degeneration in Non-neovascular AMD (2017, background): “With Bruch’s membrane, it maintains the outer blood retinal barrier to provide selective entry and removal of metabolites and molecules to and from the retina and systemic circulation (Strauss, 2005).”
- Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies. (2015, neutral): “6,7 In preclinical models, transplantation of hESC-retinal pigment epithelium resulted in extensive photoreceptor rescue and improvement in visual function.”