Pervasive roles of microRNAs in cardiovascular biology

By E. Small, E. Olson. Nature, 2011

1,225 citations recorded by the source corpus.

First recognized as regulators of development in worms and fruitflies, microRNAs are emerging as pivotal modulators of mammalian cardiovascular development and disease. Individual microRNAs modulate the expression of collections of messenger RNA targets that often have related functions, thereby governing complex biological processes. The wideranging functions of microRNAs in the cardiovascular system have provided new perspectives on disease mechanisms and have revealed intriguing therapeutic targets, as well as diagnostics, for a variety of cardiovascular disorders.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b44c542f588b53dabe4d4def6eabe819efab52c0

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Citations in the corpus

Genetics and genomics of pulmonary arterial hypertension. (2013, methodology): “Small EM, Olson EN.”
Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family (2012, background): “MicroRNAs have recently emerged as important modulators of gene networks and often form intricate regulatory circuits together with transcription factors and histone modifiers to influence the expression of large numbers of genes in a biological pathway (11).”
Oncogenic Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms (2011, neutral): “AlteredmiRNA expression is linkedwith various diseases including cancer (Small and Olson, 2011).”
MicroRNAs in stress signaling and human disease (2012, background): “MicroRNAs in Cardiovascular Disease The cardiovascular system has been an especially rich source of miRNAs with roles in disease, perhaps reflecting the susceptibility of the heart and blood vessels to injury and the dependence of mammals on persistent cardiovascular function (Small and Olson, 2011)”
Transcriptional Regulation and its Misregulation in Disease (2013, neutral): “Specific miRNAs have been implicated in both the promotion and inhibition of differentiation into cardiac lineages, cardiac hypertrophy, vascular differentiation and erythropoiesis (Han et al., 2011; Papageorgiou et al., 2012; Small and Olson, 2011).”
The Lin28/let-7 axis regulates glucose metabolism (2011, result): “…(Figure 6E), a concept that is consistent with the hypotheses that miRNAs and RNA binding proteins regulate signaling pathways by tuning the production of a broad array of proteins rather than switching single components on or off (Kennell et al., 2008; Hatley et al., 2010; Small and Olson, 2011).”
Long Noncoding RNAs in Cardiovascular Diseases (2015, neutral): “Among the noncoding RNAs, miRs have been studied extensively in the cardiovascular system, and the reader is referred to reviews summarizing the effects of miRs on cardiovascular differentiation,(1) cardiovascular aging,(2) vascular function,(3) and cardiac biology.(4,5) Particularly, the availabili”