Antisense Transcription in the Mammalian Transcriptome

By S. Katayama, Y. Tomaru, T. Kasukawa, K. Waki, M. Nakanishi, M. Nakamura, H. Nishida, C. Yap, M. Suzuki, J. Kawai and 21 more. Science, 2005

1,705 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d31adcae6e24eeb5131ac164bf3733dd2671895f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. John S. Mattick
2. Johannes Rinn
3. Howard Y. Chang
4. Ling-Ling Chen
5. David P. Bartel
6. Marcel E. Dinger
7. David L. Spector
8. Tim R. Mercer

In Molecular Biology

1. John S. Mattick
2. Howard Y. Chang
3. Johannes Rinn
4. David Haussler
5. Manolis Kellis
6. Eric S. Lander
7. Kazutaka Katoh
8. David P. Bartel

Citations in the corpus

• Ab initio reconstruction of transcriptomes of pluripotent and lineage committed cells reveals gene structures of thousands of lincRNAs (2010, background): “%) were previously identified in large scale sequencing of mouse cDNAs 24 .”
• GENCODE: The reference human genome annotation for The ENCODE Project (2012, result): “We currently group the transcripts into loci, which is different compared with other lncRNA analysis groups, for example, the Fantom Consortium (Katayama et al. 2005).”
• Diversity and dynamics of the Drosophila transcriptome (2014, neutral): “Many of these Drosophila antisense transcripts correspond to “positionally equivalent” 30 antisense transcripts in human.”
• The relationship between non-protein-coding DNA and eukaryotic complexity. (2007, background): “genes also have antisense transcripts that appear to play a role in regulation of their expression.((105)) The majority of”
• Fiber types in mammalian skeletal muscles. (2011, background): “Antisense transcription is common in the regulation of mammalian genes and antisense transcripts frequently link neighboring genes into transcriptional units (324, 398).”
• Non‐coding RNAs: regulators of disease (2010, background): “Given the abundance of mammalian antisense transcripts with the potential to form dsRNA structures [132,133], such relationships between lncRNAs and small RNAs may be commonplace.”
• The Genetic Signatures of Noncoding RNAs (2009, background): “[228]) as well as of regulatory and structural ncRNAs in other animals, plants, fungi (see e.”
• miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA (2011, background): “Natural antisense transcripts (NATs) refer to gene overlapping antisense transcription, which is detected in B70% of protein coding genes in mouse (Katayama et al, 2005), suggesting an important widespread role in regulation.”
• Regulatory roles of natural antisense transcripts (2009, background): “Both sense and antisense RNAs can encode proteins or be non-protein-coding transcripts; however, the most prominent form of antisense transcription in the mammalian genome is a non-protein-coding antisense RNA partner of a protein-coding transcrip”