Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.
By M. Fang, Yimin Wang, Ni Ai, Z. Hou, Yi Sun, Hong Lu, W. Welsh, Chung S. Yang. Cancer Research, 2003
1,092 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/d2355d2181d2132e81bfcffaab23a3377eae366e
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Citations in the corpus
- Molecular targets of dietary agents for prevention and therapy of cancer. (2006, background): “[223] Fang MZ, Wang Y, Ai N, Hou Z, Sun Y, Lu H, et al.”
- New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate (2014, background): “EGCG inhibits DNA methyltransferase (DNMT) which reverses methylationinduced gene silencing by directly binding to DNMT with an IC50 of less than 1 μM EGCG [26].”
- Epigenetics and gene expression (2010, background): “Fang et al., 2003 Examination of methytlation status of CpG islands in the promoter region of various genes, due to treatment of human esophageal cancer KYSE 510 cells with (-)-epigallocatechin-3gallate (EGCG), the major polyphenol from green tea, which is suggested to inhibit DNMT activity and…”
- Child health, developmental plasticity, and epigenetic programming. (2011, background): “Lastly, the major polyphenol in green tea, epigallocatechin-3-gallate, has been reported to inhibit DNMT and reactivate methylation-silenced genes in human esophageal squamous cell carcinoma cell lines (542).”
- The role of IL-6 and STAT3 in inflammation and cancer. (2005, background): “EGCG also inhibits the activity of the human DNA methyltransferase-1 enzyme (DNMT-1), the maintenance enzyme implicated in the epigenetic alterations leading to promoter hypermethylation in tumour cells [104].”
- The epigenomics of cancer. (2007, background): “Although procainamide (Cornacchia et al., 1988) and tea polyphenols (Fang et al., 2003) have been reported to be DNA methylation inhibitors, they are, at best, weak inhibitors in living cells (Chuang et al., 2005), and research to discover other inhibitors remains a high priority.”
- Mechanisms of combined action of different chemopreventive dietary compounds (2008, background): “expression. Both EGCG [ 40 ] and genistein [41] have been shown to reactivate a number of key”