An Adipocyte-Derived Plasma Protein, Adiponectin, Adheres to Injured Vascular Walls

By Y. Okamoto, Y. Arita, M. Nishida, M. Muraguchi, N. Ouchi, Masahiko Takahashi, T. Igura, Yoshiaki Inui, S. Kihara, Tadashi Nakamura and 4 more. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2000

596 citations recorded by the source corpus.

Subfields: Epidemiology

View Paper: https://www.semanticscholar.org/paper/d202e95fdf312c5a5b6bc55edbbb0b41f9a5470b

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In Epidemiology

1. N. Ouchi
2. T. Funahashi
3. I. Shimomura
4. Yuji Matsuzawa
5. S. Kihara
6. F. B. Hu
7. G. Hotamisligil
8. N. Rifai

Citations in the corpus

• Adiponectin: more than just another fat cell hormone? (2003, background): “It also inhibits proliferation of vascular smooth muscle cells (20) and concentrates within the vascular intima of catheter-injured vessels (21).”
• Regulation of energy metabolism by long-chain fatty acids. (2014, background): “Moreover, adiponectin binds to the site of injured artery, but not normal artery [208], suggesting the formation of the adiponectin-T-cadherin complex may facilitate the repair process by maintaining the perfusion of the injured site with interstitial fluid.”
• Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. (2001, unknown): “In addition, adiponectin was detectable in catheter-injured vessel wall, rather than in intact vessels in animal models (14).”
• PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. (2001, background): “In mechanically injured vascular walls, adiponectin could be detected in the subendothelial space (17).”
• Adiponectin Regulation and Function (2018, unknown): “In the vascular wall, adiponectin suppresses the endothelial inflammatory response, macrophage to foam cell transformation and vascular smooth muscle proliferation (226).”
• Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. (2001, background): “Adiponectin bound to collagens I, III, and V (major components of the vascular intima) in a solid-phase binding assay and accumulated in the vascular wall when the endothelial barrier was damaged (15).”
• Plasma adiponectin levels and risk of myocardial infarction in men. (2004, background): “It was shown that adiponectin binds to subendothelial collagens and suppresses proliferation and migration of human aortic smooth muscle cells.(22,56) In apolipoprotein E–deficient mice, adiponectin significantly reduced the development of atherosclerosis that usually occurs in these animals.”