Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys.

By K. Hotta, T. Funahashi, N. Bodkin, H. Ortmeyer, Y. Arita, B. Hansen, Y. Matsuzawa. Diabetes, 2001

1,133 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/0bcedc1023614d402e5810fb973c0181a737311a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. H. Fang
2. R. L. Judd
3. P. Scherer
4. P. Havel
5. Haiming Cao
6. G. Hotamışlıgil
7. Liangyou Rui
8. Sushil Kumar Jain

In Epidemiology

1. P. Scherer
2. B. Spiegelman
3. H. Fang
4. R. L. Judd
5. E. Rosen
6. Haiming Cao
7. J. Díez
8. A. Berg

In Physiology

1. P. Scherer
2. B. Spiegelman
3. H. Fang
4. R. L. Judd
5. E. Rosen
6. Haiming Cao
7. P. Havel
8. G. Hotamışlıgil

Citations in the corpus

• Insulin resistance and chronic cardiovascular inflammatory syndrome. (2003, neutral): “Interestingly, adiponectin is paradoxically decreased in obesity (293–295) in parallel with reduced insulin sensitivity (294, 295).”
• Adiponectin: more than just another fat cell hormone? (2003, background): “Circulating adiponectin levels have been shown to decrease in parallel with progression of insulin resistance during development of type 2 diabetes in rhesus monkeys genetically predisposed to develop insulin resistance (37).”
• Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. (2003, background): “Finally, a longitudinal study in rhesus monkeys demonstrated a significant association between insulin sensitivity and plasma adiponectin, along with a progressive decline in adiponectin with the development of obesity and insulin resistance (38).”
• The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. (2003, positive): “Adipose mRNA expression and plasma concentration of adiponectin are decreased dramatically in a variety of animal models as well as clinical patients with obesity, type 2 diabetes, and coronary heart disease (20, 46, 47).”
• Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. (2001, background): “Longitudinal studies in rhesus monkeys revealed that plasma Acrp30 levels declined at an early phase of obesity, and continued to decrease after the development of type 2 diabetes (19).”
• Adiponectin Regulation and Function (2018, positive): “These and additional studies in which adiponectin or HMW/LMW levels were reduced (11, 94, 110, 158, 171, 191, 241, 308) or increased (45, 230, 351, 389, 400) clearly demonstrate that adiponectin promotes insulin sensitivity and decreases insulin resistance (271).”