Plasma adiponectin levels and risk of myocardial infarction in men.
By T. Pischon, C. Girman, G. Hotamisligil, N. Rifai, F. B. Hu, E. Rimm. Journal of the American Medical Association (JAMA), 2004
1,722 citations recorded by the source corpus.
CONTEXT Adiponectin, a recently discovered adipocyte-derived peptide, is involved in the regulation of insulin sensitivity and lipid oxidation and, purportedly, in the development of atherosclerosis and coronary heart disease in humans. OBJECTIVE To assess prospectively whether plasma adiponectin concentrations are associated with risk of myocardial infarction (MI). DESIGN, SETTING, AND PARTICIPANTS Nested case-control study among 18 225 male participants of the Health Professionals Follow-up Study aged 40 to 75 years who were free of diagnosed cardiovascular disease at the time of blood draw (1993-1995). During 6 years of follow-up through January 31, 2000, 266 men subsequently developed nonfatal MI or fatal coronary heart disease. Using risk set sampling, controls were selected in a 2:1 ratio matched for age, date of blood draw, and smoking status (n = 532). MAIN OUTCOME MEASURE Incidence of nonfatal MI and fatal coronary heart disease by adiponectin level. RESULTS After adjustment for matched variables, participants in the highest compared with the lowest quintile of adiponectin levels had a significantly decreased risk of MI (relative risk [RR], 0.39; 95% confidence interval [CI], 0.23-0.64; P for trend <.001). Additional adjustment for family history of MI, body mass index, alcohol consumption, physical activity, and history of diabetes and hypertension did not substantively affect this relationship (RR, 0.41; 95% CI, 0.24-0.70; P for trend <.001). Further adjustment for hemoglobin A1c or C-reactive protein levels also had little impact, but additional adjustment for low- and high-density lipoprotein cholesterol levels modestly attenuated this association (RR, 0.56; 95% CI, 0.32-0.99; P for trend =.02). CONCLUSIONS High plasma adiponectin concentrations are associated with lower risk of MI in men. This relationship can be only partly explained by differences in blood lipids and is independent of inflammation and glycemic status.
Subfields: Oncology, Public Health, Environmental and Occupational Health, Rheumatology
View Paper: https://www.semanticscholar.org/paper/a807f5bb477e935fb30c22b615167f0fd51382d0
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Citations in the corpus
- The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019) (2019, background): “increase of thromboembolism by hypoadiponectinemia [573] and increase in plasminogen activator inhibitor [574].”
- Adipose tissue-derived factors: impact on health and disease. (2006, background): “tin levels decrease the risk of myocardial infarction (108).”
- Obesity and inflammation: the linking mechanism and the complications (2016, background): “In healthy adults with adiponectin levels within the upper 20% range, it was noted that they have 2-fold reduced risk of myocardial infarction [112], and have 7-fold reduced risk of progression of coronary artery calcification [113].”
- Adiponectin Regulation and Function (2018, neutral): “A large number of rodent and human studies have demonstrated that adiponectin has anti-inflammatory properties in various disease states, including type 2 diabetes, nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (84, 234, 254).”
- Metabolic Syndrome: Updates on Pathophysiology and Management in 2021 (2022, background): “Several studies have shown decreased adiponectin levels in patients with coronary heart disease [47,48], diabetes [49], and hypertension [50] compared to control subjects, thus conferring a protective role for adiponectin against the development and progression of insulin resistance, high blood pres”
- Adiponectin: mechanistic insights and clinical implications (2012, background): “In a 2004 landmark study, Pischon and colleagues established in a very large cohort that high plasma adiponectin concentrations are associated with a lower risk of myocardial infarction in men [28].”