Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases.

By Kendra D. Martyn, Linda M Frederick, Katharina von Loehneysen, M. Dinauer, U. Knaus. Cellular Signalling, 2006

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View Paper: https://www.semanticscholar.org/paper/d1c8ef00e9890050778090279688435ba19cce2e

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Citations in the corpus

Crosstalk between mitochondria and NADPH oxidases (2011, background): “Nox4 and Nox5 do not require p47phox or Rac1 subunits [105].”
Reactive Oxygen Species in Inflammation and Tissue Injury (2014, positive): “However, NOX4 activity required the presence of p22 (275).”
Uric Acid: The Oxidant-Antioxidant Paradox (2008, background): “[35] On the other hand, activation of NOX4, a predominant NADPH oxidase in our adipocyte model, generally does not require translocation of cytoplasmic subunits;[48] therefore, the mechanism of activation of NOX4 by uric acid remains to be determined.”
Regulation of reactive oxygen species generation in cell signaling (2011, background): “Nox1, Nox3, and Nox4 have similar structure with Nox2 and then categorized into prototype.”
Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes (2006, positive): “Transfected Nox4 also colocalizes with PTP1B in COS7 cells, and Nox4 enhances insulin receptor tyrosine phosphorylation through PTP1B inactivation , which is again consistent with spatial coordination between oxidant source and target (Mahadev et al., 2004; Martyn et al., 2006).”
Nox family NADPH oxidases: Molecular mechanisms of activation. (2014, background): “Nox1, Nox2, and Nox3 [3] interact with the small transmembrane protein p22phox, and although Nox4 also shows this interaction [4], it appears to be somewhat different than the other Nox enzymes [5].”
NADPH Oxidases in Cardiovascular Health and Disease (2006, positive): “activity but other subunits do not appear to be required (8, 229).”
Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. (2007, background): “What kind of cytoplasmic regulatory subunits are expressed in these cells remains unknown, although NOX4, in contrast to other NADPH oxidases, does not require cytoplasmic proteins for its activity (35).”