Iron Metabolism in Ferroptosis
By Xin Chen, Chunhua Yu, R. Kang, D. Tang. Frontiers in Cell and Developmental Biology, 2020
833 citations recorded by the source corpus.
Ferroptosis is a form of regulated cell death that is characterized by iron-dependent oxidative damage and subsequent plasma membrane ruptures and the release of damage-associated molecular patterns. Due to the role of iron in mediating the production of reactive oxygen species and enzyme activity in lipid peroxidation, ferroptosis is strictly controlled by regulators involved in many aspects of iron metabolism, such as iron uptake, storage, utilization, and efflux. Translational and transcriptional regulation of iron homeostasis provide an integrated network to determine the sensitivity of ferroptosis. Impaired ferroptosis is implicated in various iron-related pathological conditions or diseases, such as cancer, neurodegenerative diseases, and ischemia-reperfusion injury. Understanding the molecular mechanisms underlying the regulation of iron metabolism during ferroptosis may provide effective strategies for the treatment of ferroptosis-associated diseases. Indeed, iron chelators effectively prevent the occurrence of ferroptosis, which may provide new approaches for the treatment of iron-related disorders. In this review, we summarize recent advances in the theoretical modeling of iron-dependent ferroptosis, and highlight the therapeutic implications of iron chelators in diseases.
Subfields: Cancer Research, Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/8b67ce790b37710ad45fdad78d427ef52be0c3c0
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Citations in the corpus
- Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies (2024, background): “91 Therefore, interventions that modulate the import, storage, and export of iron in the cytoplasm contribute to an increase in susceptibility to ferroptosis.”
- Ferroptosis in infection, inflammation, and immunity (2021, background): “In theory, increasing the concentration of free intracellular iron by intervening at any level of iron metabolism (including its absorption, storage, utilization, and outflow) can induce ferroptosis (Chen et al., 2020b).”
- Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis (2022, background): “Ferroptosis is a highly regulated ROS-dependent type of cell death, derived from free iron overload (FIO) [13].”
- Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “Increased iron accumulation is a key trigger of ferroptosis in animal models.(73) Specifically, transferrin promotes ferroptosis by mediating iron uptake through the transferrin receptor (TFRC).”