Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

By L. Mei, W. Xiong. Nature Reviews Neuroscience, 2008

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Interneuron dysfunction in psychiatric disorders (2012, background): “Considering that NRG1 and ERBB4 are encoded by genes that have been repeatedly linked to schizophreni”
Signals of recent positive selection in a worldwide sample of human populations. (2009, background): “We return briefly to this point in the Discussion.”
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 (2009, neutral): “Both AKT1 and its upstream activator NRG1 have been identified as susceptibility genes for schizophrenia (Emamian et al., 2004; Mei and Xiong, 2008; Stefansson et al., 2002; Tosato et al., 2005).”
Animal models of schizophrenia (2011, background): “…of NRG1 [Nrg1(DTM)+/-], deletions of the immunoglobulin (Ig) domain [Nrg1(DIg)+/-] and homozygous deletions of NRG1-cleaving enzyme BACE [Nrg1(BACE)-/-] all show distinct, varied schizophrenia-related alterations in behaviour and pathophysiology (Mei and Xiong, 2008; Jaaro-Peled et al., 2010).”
Dendritic spine pathology in neuropsychiatric disorders (2011, background): “Polymorphisms in NRG1 are associated with schizophreni”