Wnt signalling regulates adult hippocampal neurogenesis

By D. C. Lie, S. Colamarino, Hong-jun Song, L. Désiré, Helena Mira, A. Consiglio, E. Lein, Sebastian Jessberger, Heather Lansford, Alejandro R. Dearie and 1 more. 2005

1,565 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

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Citations in the corpus

Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement (2014, background): “…et al., 2008; Waterhouse et al., 2012 GABA Neurotransmitter DG Ge et al., 2006 Glutamate Neurotransmitter SVZ Platel et al., 2010 WNT Morphogen DG Lie et al., 2005; Kuwabara et al., 2009 INTRACELLULAR FACTORS NFATc4 Transcription factor DG Quadrato et al., 2012 NF-KappaB p50 Transcription factor…”
Adult neurogenesis and functional plasticity in neuronal circuits (2006, background): “Another extremely important signalling system during development, the WNT system, also augments neurogenic proliferation in the adult dentate gyru”
Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells (2010, methodology): “To confirm that loss of Fmrp led to the deficit in the Wnt signaling pathway, we used a well-characterized luciferase reporter system for monitoring the activity of the Wnt signaling pathway [26,49].”
DISC1 regulates neural progenitor proliferation via modulation of GSK3β/β-catenin signaling (2009, background): “Together, these results implicate DISC1 in GSK3b/b-catenin signaling pathways and provide a framework for understanding how alterations in this pathway may contribute to the etiology of psychiatric disorders.”
GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus (2009, methodology): “immunostaining as previously described (Lie et al., 2005).”
Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus (2006, background): “, 2001), Wnt (Lie et al., 2005), or Sonic hedgehog signaling (Lai et al.”
Molecular mechanisms of neurodegeneration in Alzheimer's disease. (2010, background): “Mechanisms of neurogenesis in the fetal brain have been extensively studied, and pathways such as the wnt (67) and Notch (68,69) signaling cascades play an important role in this process.”
The potential of neural stem cells to repair stroke-induced brain damage (2009, background): “During post-ischemic striatal neurogenesis, -catenin mediates the activation of transcription in the SVZ progenitor cells, allowing them to proliferate and diVerentiate [ 64 ].”
Mechanisms and functional implications of adult neurogenesis. (2008, neutral): “Blockade of the Wnt signaling pathway inhibits the neurogenic activity of astrocytes in vitro and SGZ neurogenesis in vivo, suggesting that hippocampal astrocytes may act through Wnt signaling (Lie et al., 2005).”
Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. (2007, methodology): “Cell proliferation analyses were performed as described (Lie et al., 2005).”
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis (2011, methodology): “To block β-catenin signaling, we cloned a dnLEF (7) into the same retroviral backbone.”
Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. (2010, background): “, 2009) and Wnt3 (Lie et al., 2005) may be relevant (Figure S7).”
Emerging roles of Wnts in the adult nervous system (2010, background): “More recent studies provide evidence that Wnt signalling enhances the proliferation of neural stem cells derived from the adult CN”