The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

By Toshimasa Yamauchi, J. Kamon, H. Waki, Y. Terauchi, N. Kubota, K. Hara, Y. Mori, T. Ide, K. Murakami, N. Tsuboyama-Kasaoka and 15 more. Nature Medicine, 2001

5,108 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/d051a09f99ab837fa58437f0c6dbaccb02c7e037

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In Endocrine and Autonomic Systems

In Epidemiology

In Physiology

Citations in the corpus

Adipokines: inflammation and the pleiotropic role of white adipose tissue (2004, background): “However, the principal reason for the recent focus on adiponectin is the evidence that it is involved in modulating insulin sensitivity (Berg et al. 2001; Yamauchi et al. 2001), as well as having anti-atherogeneic properties (Engeli et al. 2003).”
Endocrine regulation of energy metabolism by the skeleton. (2007, background): “On the other hand, expression and serum level of adiponectin, an adipokine enhancing insulin sensitivity (Yamauchi et al., 2001), were respectively increased 3- and 2-fold in Esp / mice (Figures 2L and 2M).”
Homeostasis, Inflammation, and Disease Susceptibility (2015, neutral): “Examples of these signals include the adipokines leptin (Friedman and Halaas, 1998), adiponectin (Yamauchi et al., 2001), and RBP4 (Yang et al.”
Adiponectin and adiponectin receptors. (2005, background): “In an attempt to identify insulin-sensitizing molecules secreted from white adipose tissue of heterozygous PPAR knockout mice, oligonucleotide microarray analysis was carried out using white adipose tissue (39).”
Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. (2002, background): “Recently the adipocyte-derived hormone adiponectin has been shown to reverse insulin resistance associated with both lipoatrophy and obesity (152).”
PPARs and the complex journey to obesity (2004, background): “As a result, hepatic glucose production is reduced and muscle glucose use is increase”
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009 (2010, background): “Adiponectin is a potent insulin sensitiser in muscle and liver [184] and exerts multiple anti-atherogenic effects [185, 186].”