Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

By Miia Kivipelto, E. Helkala, M. Laakso, T. Hänninen, M. Hallikainen, K. Alhainen, Hilkka Soininen, J. Tuomilehto, A. Nissinen. British medical journal, 2001

1,682 citations recorded by the source corpus.

Subfields: Physiology, Psychiatry and Mental health, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/d049f3de38157d79d9abd56d49f32990cc1d17f8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Physiology

1. K. Simons
2. Christian Haass
3. K. Jellinger
4. R. Ehehalt
5. C. Dart

In Psychiatry and Mental health

1. C. Qiu
2. K. Jellinger
3. Miia Kivipelto
4. E. von Strauss

Citations in the corpus

• Inequalities in dementia incidence between six racial and ethnic groups over 14 years (2016, background): “Prior studies have demonstrated that associations between midlife vascular risk factors and late-life dementia risk are stronger than associations for vascular risk factors measured in late-life [26,40–42].”
• Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts (2003, background): “, 1998), and there is epidemiological evidence that elevated cholesterol levels during mid-life increase the risk of developing AD (Kivipelto et al., 2001).”
• Therapeutics of Alzheimer's disease: Past, present and future. (2014, background): “The greatest risk factor is advancing age; others being a positive family history, head trauma, female gender, previous depression, diabetes mellitus, hyperlipidemia and vascular factors (Kivipelto et al., 2001).”
• Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention (2009, result): “Elevated blood pressure in middle age, especially uncontrolled midlife high blood pressure, was linked to an increased risk of late-life AD in several observational studies.(72,73) Findings from follow-up studies of late-life blood pressure in relation to the risk of dementia have been inconsistent;”
• Alzheimer disease and cerebrovascular pathology: an update (2002, background): “An association between hypertension and AD has been reported in several prospective studies (Skoog et al., 1993, 1996; Hofman et al., 1997; Skoog, 2000; Launer et al., 2000; Meyer et al., 2000; Schmidt et al., 2000; Kivipelto et al., 2001).”
• Inflammation as a central mechanism in Alzheimer's disease (2018, background): “[237] Kivipelto M1, Helkala EL, Laakso MP, H€anninen T, Hallikainen M,”
• Measures of brain morphology and infarction in the framingham heart study: establishing what is normal. (2005, background): “Accelerated brain aging due to cerebrovascular disease as seen in this study may help to explain the increased prevalence of mild cognitive impairment [17,19,45,56] and dementia (including Alzheimer’s disease) [46,47,49,84–86] associated with cerebrovacular risk factors and MRI infarctions [100].”