Alzheimer disease and cerebrovascular pathology: an update

By K. Jellinger. Journal of neural transmission, 2002

693 citations recorded by the source corpus.

Subfields: Neurology, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/a85eb74a03a839e03be15aae39b2a0be2d5ec59d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

In Physiology

In Psychiatry and Mental health

Citations in the corpus

Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence (2017, background): “Radiation is also a risk factor for early dementia, however links to an increased risk of Alzheimer’s disease (AD) lack solid epidemiological evidence, despite the fact that AD is characterized by Aβ plaque formation in the brain parenchyma and that CAA occurs in more than 80% of AD patients [6-8].”
Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. (2006, background): “CAA is present in up to 80% of cases of AD diagnosed at autopsy (Jellinger, 2002; Weller et al., 2000, 2004), suggesting that cerebrovascular disease may be a factor in the failure of elimination of Aβ from the brain in AD, linking aging in cerebral arteries with the pathogenesis of AD (Nicoll et…”
The blood-brain barrier in Alzheimer's disease (2017, positive): “Furthermore, the expression of occludin, claudin-5, and ZO-1 was strongly suppressed in the A β -laden capillaries of patients with capillary CAA, suggesting that the modulation of TJ protein expression may increase vascular permeability in the AD brain (Carrano et al., 2011; Carrano et al., 2012).”
The overlap between vascular disease and Alzheimer’s disease - lessons from pathology (2014, background): “, hypertensive vasculopathy), or microvascular degeneration (tortuosity, fibro- and lipohyalinosis,); – Blood–brain barrier (BBB) dysfunction causing white matter lesions (WMLs), microinfarctions, lacunes or lacunar infarcts, and microbleeds [17,87].”
Post-stroke cognitive impairment: epidemiology, mechanisms and management. (2014, background): “The CAA, which is a common cause of the stroke especially the hemorrhage stroke, is found in about 90% cases of AD (60,72).”
Alzheimer’s disease: experimental models and reality (2017, background): “Hence, the preclinical testing of therapeutic approaches in models with extensive CAA (which virtually all individuals with AD and about a third of aged cognitively normal individuals have) [68, 179] and showing that it does not induce microhemorrhages is of importance.”