Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention

By C. Qiu, Miia Kivipelto, E. von Strauss. Dialogues in Clinical Neuroscience, 2009

1,175 citations recorded by the source corpus.

More than 25 million people in the world today are affected by dementia, most suffering from Alzheimer's disease. In both developed and developing nations, Alzheimer's disease has had tremendous impact on the affected individuals, caregivers, and society. The etiological factors, other than older age and genetic susceptibility, remain to be determined. Nevertheless, increasing evidence strongly points to the potential risk roles of vascular risk factors and disorders (eg, cigarette smoking, midlife high blood pressure and obesity, diabetes, and cerebrovascular lesions) and the possible beneficial roles of psychosocial factors (eg, high education, active social engagement, physical exercise, and mentally stimulating activity) in the pathogenetic process and clinical manifestation of the dementing disorders. The long-term multidomain interventions toward the optimal control of multiple vascular risk factors and the maintenance of socially integrated lifestyles and mentally stimulating activities are expected to reduce the risk or postpone the clinical onset of dementia, including Alzheimer's disease.

Subfields: Complementary and alternative medicine, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/dfc15a3e96dcd8723798bfe8952bb50795b798c5

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Citations in the corpus

Alzheimer's Disease: Targeting the Cholinergic System (2016, background): “The rapid progression of the disease has a great impact for the affected individual, their family members, caregivers and society [204].”
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. (2012, background): “In that age bracket, when the incidence of AD begins to rise sharply (159), it is estimated that 67% of the US populace is either diabetic or prediabetic (158).”