Molecular mechanisms of blood vessel growth.

By E. Conway, D. Collen, Peter Carmeliet. Cardiovascular Research, 2001

1,071 citations recorded by the source corpus.

Subfields: Cancer Research, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d0372dd079e34700c9368cc8f3dff9cf917d023d

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Citations in the corpus

Regulation of angiogenesis by hypoxia: role of the HIF system (2003, background): “Effects of hypoxia on molecular determinants of angiogenesis Angiogenesis is a complex process, involving multiple gene products expressed by different cell types, all contributing to an integrated sequence of event”
HIF-1α pathway: role, regulation and intervention for cancer therapy (2015, background): “HIF-1α mRNA expression EZN-2698 (1) HIF-1α mRNA Aminoflavone (2) HIF-1α translation CPTs (3): Topoisomerase I topotecan (3a), EZN-2208 (3b), SN38 (3c), irinotecan (3d) Temsirolimus (4) mTOR Everolimus (4a) Sirolimus (4b) LY294002 (5) PI3K Wortmannin (6) Cardiac glycosides (7): HIF-1α protein/HIF-2α ”
Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “The initial stage of tumor growth is an avascular state, in which the tumor has not acquired aggressiveness and absorbs oxygen and nutrients through the diffusion of surrounding tissue.(14) Therefore, tumor angiogenesis is locked or limited to a quiescent status owing to the low levels of pro-angiog”
Origin of endothelial progenitors in human postnatal bone marrow. (2002, result): “The degree of contribution of endothelial cells to tumor angiogenesis and to neoangiogenesis was 35–45%, levels similar to those described for other sources of endothelial cells (42, 43).”
Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. (2007, neutral): “The assay mix contained the following probes and primers: (1) forward primer: 5 -AAGCTTTCTCACAAGCATTTGGTTT-3 ; (2) reverse primer: 5 -AGAAAGGCATTAGAAAGCCTGTAGTT-3 ; (3) VIC-labeled oligo: 5 -TCTCCACAGACACATAC-3 ; (4) FAM-labeled oligo: 5 -TCCACAGAAACATAC-3 .”
Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds (2014, neutral): “This process is tightly regulated by a series of angiogenic growth factors, especially vascular endothelial growth factor (VEGF) and platelet-derived growth factor-BB (PDGF-BB), which act in a sequential fashion to stimulate and stabilize blood vessel growth, respectively [5,8].”
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy (2015, background): “mediated through stimulation of pro-angiogenic molecule production such as VEGF-R2 (Flk-1), members of the FGF family and PDGF, important in the primitive vascular network formation.(64,66) ii) Hypoxia and HIF-α are also involved in the angiogenesis process by inducing enzymes’ expression (ie, MMPs)”
Engineering Complex Tissues (2006, neutral): “Angiogenesis occurs either via the sprouting of new vessels from the sides and ends of existing vessels or via the longitudinal division of a vessel.(233) Vascular endothelial growth factor (VEGF) initiates activation, migration, and proliferation of endothelial cells to form immature new vessels, a”