HIF-1α pathway: role, regulation and intervention for cancer therapy

By Georgina N. Masoud, Wei Li. Acta Pharmaceutica Sinica B, 2015

1,722 citations recorded by the source corpus.

Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. Many recent studies have provided convincing evidences of strong correlation between elevated levels of HIF-1 and tumor metastasis, angiogenesis, poor patient prognosis as well as tumor resistance therapy. It was found that hypoxia (low O2 levels) is a common character in many types of solid tumors. As an adaptive response to hypoxic stress, hypoxic tumor cells activate several survival pathways to carry out their essential biological processes in different ways compared with normal cells. Recent advances in cancer biology at the cellular and molecular levels highlighted the HIF-1α pathway as a crucial survival pathway for which novel strategies of cancer therapy could be developed. However, targeting the HIF-1α pathway has been a challenging but promising progresses have been made in the past twenty years. This review summarizes the role and regulation of the HIF-1α in cancer, and recent therapeutic approaches targeting this important pathway.

Subfields: Cancer Research, Hepatology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2dcaa6fa3fb188cfdc79dfe51c0a1a468d988254

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Citations in the corpus

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs (2018, background): “In literature, it was also reported that HIF‐1 regulates the expression of several antiapoptotic factors (e.g., Bak, Bax, Bcl‐xL, Bcl‐2, Bid, Mcl‐1, NF‐κB, p53, and survivin; Masoud & Li, 2015; Rohwer & Cramer, 2011).”
Targeting Tumor Microenvironment for Cancer Therapy (2019, background): “This response to low oxygen pressure levels includes regulation of genes involved in glucose metabolism, cell proliferation, angiogenesis, macrophage polarization into tumor-associated macrophages (TAM) and metastasis (reviewed in [11,19]).”
Tumor angiogenesis and vascular normalization: alternative therapeutic targets (2017, background): “Recently, it was demonstrated that the ERK signaling cascade can result in the increased rate of mRNA translation of HIF1 protein [51].”
Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “4).(151,239) However, since the hydroxylation under hypoxic conditions can be limited by oxygen concentration, HIF-1α constitutes a dimerized complex with HIF-1β through nuclear translocation.”
The Roles of Autophagy in Cancer (2018, background): “and regulates many of its target genes [95].”