The Arabidopsis Transcription Factor MYB12 Is a Flavonol-Specific Regulator of Phenylpropanoid Biosynthesis1

By Frank Mehrtens, H. Kranz, P. Bednarek, Bernd Weisshaar. Plant Physiology, 2005

781 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/ceb964593f6cf81d714f31a943ca65bd7b5331e0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Plant Science

Citations in the corpus

Enhancement of oxidative and drought tolerance in Arabidopsis by overaccumulation of antioxidant flavonoids (2013, background): “The dominant flavonoids in MYB12OX and pap1-D are flavonol glycosides and anthocyanins (Mehrtens et al., 2005; Tohge et al., 2005a; Stracke et al., 2010b).”
Evolutionary and comparative analysis of MYB and bHLH plant transcription factors. (2011, background): “Maize ZmP1 is a member of the recently amplified sub-group 7, whose members in Arabidopsis and grapevine control flavonol accumulation, and possibly also include early flavonoid biosynthetic genes (Table 2) (Mehrtens et al., 2005; Czem- mel et al., 2009).”
Plant phenolics: recent advances on their biosynthesis, genetics, and ecophysiology. (2013, background): “Furthermore, production of 3deoxyflavonoids (in grasses) and flavonols is controlled by R2R3MYBs that do not require a bHLH partner [72,73].”
Transient expression vectors for functional genomics, quantification of promoter activity and RNA silencing in plants (2005, background): “MdMYB22 has sequence homology to the maize P gene [GenBank: M73029] and AtMYB12 [AT2G47460] which has been shown to regulate genes involved in the flavanol biosynthesis pathway [20].”
Flavonoids as Important Molecules of Plant Interactions with the Environment (2014, background): “In many plant species, MYB proteins were reported to be capable of regulating the biosynthesis of flavonoids and to be induced by stress, exemplified by Arabidopsis MYB75 (PAP1), AtMYB90 (PAP2) MYB12 and MYBL2 [120,126,127], petunia AN2 and PH4 [128,129], grape MYBA1 and MYBA2 [130–133], sweet potat”
Light-Induced Expression of a MYB Gene Regulates Anthocyanin Biosynthesis in Red Apples1 (2006, background): “…Arabidopsis, specific MYB regulators of these pathways have been found, for example AtMYB12 is a regulator of AtCHS and AtFLS, which are required for flavonol synthesis (Mehrtens et al., 2005), while AtTT2 regulates AtDFR, AtLDOX, and AtANR, which are required for CT synthesis (Nesi et al., 2001).”
Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling (2007, methodology): “The flavonoid biosynthesis enzymes reporter constructs and the MYB12 effector construct have been described previously (Mehrtens et al., 2005).”
New insights into the shikimate and aromatic amino acids biosynthesis pathways in plants. (2010, background): “The TF MYB12 of Arabidopsis is a specific activator of flavonoid biosynthesis, regulating the expression of genes encoding various enzymes of flavonoid biosynthesis, including chalcone synthase, chalcone flavanone isomerase, flavanone 3-hydroxylase, and flavonol synthase (Mehrtens et al., 2005).”
Analysis of Transcription Factor HY5 Genomic Binding Sites Revealed Its Hierarchical Role in Light Regulation of Development[W] (2007, methodology): “For RNA expression analysis, RNA gel blot analysis and reverse transcription–coupled PCR analysis were performed according to the procedures described previously (Moon et al., 2005; Ryu et al., 2005).”